GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

Abstract Background GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in the gastrointestinal mucosa and inflamed skin. Emerging evidence suggests its involvement in inflammatory disorders and cancers. C-X-C chemokine receptor type 4 (CXCR4) play...

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Main Authors: Dan Pascal Jean Albers, Sofya Novikova, Julio Vieyto-Nuñez, Yasser Almeida-Hernández, Chiara Pastorio, Florian Klassen, Dana Weiss, Pascal von Maltitz, Janeni Jaikishan, Moumita Datta, Hassan Jumaa, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer, Manish Kumar, Palash Chandra Maity, Christian Buske, Ulrich Stifel, Julia Zinngrebe, Pamela Fischer-Posovszky, Andy Chevigné, Frank Kirchhoff, Elsa Sanchez-Garcia, Jan Münch, Mirja Harms
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
GPR15LG
CXCR4 signaling
Immune cell migration
Cancer metastasis
Wound healing
Online Access:https://doi.org/10.1186/s12964-025-02231-x
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