Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa.
<h4>Objective</h4>To describe associations of high-risk human papillomavirus (HR-HPV) with high-grade cervical intraepithelial neoplasia (CIN2+) in women living with HIV (WLHIV) in Burkina Faso (BF) and South Africa (SA).<h4>Methods</h4>Prospective cohort of WLHIV attending H...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0174117&type=printable |
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| author | Helen A Kelly Jean Ngou Admire Chikandiwa Bernard Sawadogo Clare Gilham Tanvier Omar Olga Lompo Sylviane Doutre Nicolas Meda Helen A Weiss Sinead Delany-Moretlwe Michel Segondy Philippe Mayaud HARP Study Group |
| author_facet | Helen A Kelly Jean Ngou Admire Chikandiwa Bernard Sawadogo Clare Gilham Tanvier Omar Olga Lompo Sylviane Doutre Nicolas Meda Helen A Weiss Sinead Delany-Moretlwe Michel Segondy Philippe Mayaud HARP Study Group |
| author_sort | Helen A Kelly |
| collection | DOAJ |
| description | <h4>Objective</h4>To describe associations of high-risk human papillomavirus (HR-HPV) with high-grade cervical intraepithelial neoplasia (CIN2+) in women living with HIV (WLHIV) in Burkina Faso (BF) and South Africa (SA).<h4>Methods</h4>Prospective cohort of WLHIV attending HIV outpatient clinics and treatment centres. Recruitment was stratified by ART status. Cervical HPV genotyping using INNO-LiPA and histological assessment of 4-quadrant cervical biopsies at enrolment and 16 months later.<h4>Results</h4>Among women with CIN2+ at baseline, the prevalence of any HR-HPV genotypes included in the bi/quadrivalent (HPV16/18) or nonavalent (HPV16/18/31/35/45/52/58) HPV vaccines ranged from 37% to 90%. HPV58 was most strongly associated with CIN2+ (aOR = 5.40, 95%CI: 2.77-10.53). At 16-months follow-up, persistence of any HR-HPV was strongly associated with incident CIN2+ (aOR = 7.90, 95%CI: 3.11-20.07), as was persistence of HPV16/18 (aOR = 5.25, 95%CI: 2.14-12.91) and the additional HR types in the nonavalent vaccine (aOR = 3.23, 95%CI: 1.23-8.54).<h4>Conclusion</h4>HR-HPV persistence is very common among African WLHIV and is linked to incident CIN2+. HPV vaccines could prevent between 37-90% of CIN2+ among African WLHIV. |
| format | Article |
| id | doaj-art-b4d31feff0ae491096b63cd904362c35 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b4d31feff0ae491096b63cd904362c352025-08-20T03:24:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017411710.1371/journal.pone.0174117Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa.Helen A KellyJean NgouAdmire ChikandiwaBernard SawadogoClare GilhamTanvier OmarOlga LompoSylviane DoutreNicolas MedaHelen A WeissSinead Delany-MoretlweMichel SegondyPhilippe MayaudHARP Study Group<h4>Objective</h4>To describe associations of high-risk human papillomavirus (HR-HPV) with high-grade cervical intraepithelial neoplasia (CIN2+) in women living with HIV (WLHIV) in Burkina Faso (BF) and South Africa (SA).<h4>Methods</h4>Prospective cohort of WLHIV attending HIV outpatient clinics and treatment centres. Recruitment was stratified by ART status. Cervical HPV genotyping using INNO-LiPA and histological assessment of 4-quadrant cervical biopsies at enrolment and 16 months later.<h4>Results</h4>Among women with CIN2+ at baseline, the prevalence of any HR-HPV genotypes included in the bi/quadrivalent (HPV16/18) or nonavalent (HPV16/18/31/35/45/52/58) HPV vaccines ranged from 37% to 90%. HPV58 was most strongly associated with CIN2+ (aOR = 5.40, 95%CI: 2.77-10.53). At 16-months follow-up, persistence of any HR-HPV was strongly associated with incident CIN2+ (aOR = 7.90, 95%CI: 3.11-20.07), as was persistence of HPV16/18 (aOR = 5.25, 95%CI: 2.14-12.91) and the additional HR types in the nonavalent vaccine (aOR = 3.23, 95%CI: 1.23-8.54).<h4>Conclusion</h4>HR-HPV persistence is very common among African WLHIV and is linked to incident CIN2+. HPV vaccines could prevent between 37-90% of CIN2+ among African WLHIV.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0174117&type=printable |
| spellingShingle | Helen A Kelly Jean Ngou Admire Chikandiwa Bernard Sawadogo Clare Gilham Tanvier Omar Olga Lompo Sylviane Doutre Nicolas Meda Helen A Weiss Sinead Delany-Moretlwe Michel Segondy Philippe Mayaud HARP Study Group Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa. PLoS ONE |
| title | Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa. |
| title_full | Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa. |
| title_fullStr | Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa. |
| title_full_unstemmed | Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa. |
| title_short | Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa. |
| title_sort | associations of human papillomavirus hpv genotypes with high grade cervical neoplasia cin2 in a cohort of women living with hiv in burkina faso and south africa |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0174117&type=printable |
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