HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury

HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury

RationaleAcute kidney injury (AKI) is a clinical syndrome associated with a multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone of treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare s...

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Bibliographic Details
Main Authors: Li Zhu, Qiang Zheng, Xiaodong Liu, Hao Ding, Mengqing Ma, Jiaxin Bao, Yawen Cai, Changchun Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
lactate
HMGB1 lactylation
neutrophil extracellular traps (NETs)
acute kidney injury
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1475543/full
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