FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction

FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction

Abstract Human pancreatic islets regulate organ development and metabolic homeostasis, with dysfunction leading to diabetes. Human pluripotent stem cells (hPSCs) provide a potential alternative source to cadaveric human pancreatic islets for replacement therapy in diabetes. However, human islet-like...

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Main Authors: Clarissa Tacto, Meghan Tahbaz, Andrew Salib, Shudi Wang, Fritz Cayabyab, Jinhyuk Choi, Kiyoka Kim, Yu Hamba, Harvey Perez, Paul D. Gershon, Robert Damoiseaux, Tae Gyu Oh, Eiji Yoshihara
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60188-4
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