An Elongator mouse model of ALS spotlights TDP-43 in the motor neuron nucleolus

An Elongator mouse model of ALS spotlights TDP-43 in the motor neuron nucleolus

Abstract Dysfunction of Elongator is associated with amyotrophic lateral sclerosis (ALS). Here, we describe mouse models in which either Elongator subunit 1(Elp1) or subunit 3 (Elp3) is selectively ablated in alpha motor neurons of the spinal cord. These mice exhibit a progressive loss of motor stre...

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Bibliographic Details
Main Authors: Magge Snow, BreAnna Cameron, Renzie Pond, Rachel Trudell, Sara Snyder, Lauryn Torres-Hernandez, Devyn Deschamps, Danara Tulimaiau, Kiana Hawkinson, Morgan Russell, Danielle Horan, Joseph Walters, James H. Fox, Britni Arlian, Alain Chariot, Laurent Nguyen, Lynn George
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08701-9
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