Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust
<i>Background and Objectives</i>: Persistent exposure to airborne fine dust (FD) particles contributing to air pollution has been linked to various human health issues, including respiratory inflammation, allergies, and skin diseases. We aimed to identify potential seaweed anti-inflammat...
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2025-01-01
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| author | Eun-Gyeong Lee Sung-Kun Yim Sang-Min Kang Byung Jae Ahn Chang-Kwon Kim Mina Lee Dongseob Tark Gun-Hee Lee |
| author_facet | Eun-Gyeong Lee Sung-Kun Yim Sang-Min Kang Byung Jae Ahn Chang-Kwon Kim Mina Lee Dongseob Tark Gun-Hee Lee |
| author_sort | Eun-Gyeong Lee |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Persistent exposure to airborne fine dust (FD) particles contributing to air pollution has been linked to various human health issues, including respiratory inflammation, allergies, and skin diseases. We aimed to identify potential seaweed anti-inflammatory bioactive reagents and determine their effects on systemic inflammatory responses induced by FD particles. <i>Materials and Methods</i>: While exploring anti-inflammatory bioactive reagents, we purified compounds with potential anti-inflammatory effects from the seaweed extracts of <i>Ecklonia cava</i>, <i>Ecklonia stolonifera</i>, and <i>Codium fragile</i>. Structural analyses of the purified compounds siphonaxanthin (Sx), fucoxanthin (Fx), dieckol (Dk), and phlorofucofuroeckol-A (PFF-A) were performed using NMR and LC-MS/MS. <i>Results</i>: Notably, these compounds, especially PFF-A, showed significant protective effects against FD-induced inflammatory responses in RAW 264.7 cells without cytotoxicity. Further investigation of inflammatory-associated signaling demonstrated that PFF-A inhibited IL-1β expression by modulating the NF-κB/MAPK signal pathway in FD-induced RAW 264.7 cells. Additionally, gene profiling revealed the early activation of various signature genes involved in the production of inflammatory cytokines and chemokines using gene profiling. Treatment with PFF-A markedly reduced the expression levels of pro-inflammatory and apoptosis-related genes and even elevated the Bmp gene families. <i>Conclusions</i>: These results suggested that PFF-A is a potential natural therapeutic candidate for managing FD-induced inflammatory response. |
| format | Article |
| id | doaj-art-b4c101be63914b5ea4ea6e616f534685 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-b4c101be63914b5ea4ea6e616f5346852025-01-24T13:40:56ZengMDPI AGMedicina1010-660X1648-91442025-01-0161116510.3390/medicina61010165Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine DustEun-Gyeong Lee0Sung-Kun Yim1Sang-Min Kang2Byung Jae Ahn3Chang-Kwon Kim4Mina Lee5Dongseob Tark6Gun-Hee Lee7Laboratory for Infection Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of KoreaMarine Biotechnology Research Center, Jeonnam Bioindustry Foundation, Wando-gun 59108, Republic of KoreaLaboratory for Infection Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of KoreaMarine Biotechnology Research Center, Jeonnam Bioindustry Foundation, Wando-gun 59108, Republic of KoreaCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of KoreaCollege of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of KoreaLaboratory for Infection Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of KoreaLaboratory for Infection Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea<i>Background and Objectives</i>: Persistent exposure to airborne fine dust (FD) particles contributing to air pollution has been linked to various human health issues, including respiratory inflammation, allergies, and skin diseases. We aimed to identify potential seaweed anti-inflammatory bioactive reagents and determine their effects on systemic inflammatory responses induced by FD particles. <i>Materials and Methods</i>: While exploring anti-inflammatory bioactive reagents, we purified compounds with potential anti-inflammatory effects from the seaweed extracts of <i>Ecklonia cava</i>, <i>Ecklonia stolonifera</i>, and <i>Codium fragile</i>. Structural analyses of the purified compounds siphonaxanthin (Sx), fucoxanthin (Fx), dieckol (Dk), and phlorofucofuroeckol-A (PFF-A) were performed using NMR and LC-MS/MS. <i>Results</i>: Notably, these compounds, especially PFF-A, showed significant protective effects against FD-induced inflammatory responses in RAW 264.7 cells without cytotoxicity. Further investigation of inflammatory-associated signaling demonstrated that PFF-A inhibited IL-1β expression by modulating the NF-κB/MAPK signal pathway in FD-induced RAW 264.7 cells. Additionally, gene profiling revealed the early activation of various signature genes involved in the production of inflammatory cytokines and chemokines using gene profiling. Treatment with PFF-A markedly reduced the expression levels of pro-inflammatory and apoptosis-related genes and even elevated the Bmp gene families. <i>Conclusions</i>: These results suggested that PFF-A is a potential natural therapeutic candidate for managing FD-induced inflammatory response.https://www.mdpi.com/1648-9144/61/1/165fine dustPFF-Ainflammationseaweed extract |
| spellingShingle | Eun-Gyeong Lee Sung-Kun Yim Sang-Min Kang Byung Jae Ahn Chang-Kwon Kim Mina Lee Dongseob Tark Gun-Hee Lee Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust Medicina fine dust PFF-A inflammation seaweed extract |
| title | Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust |
| title_full | Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust |
| title_fullStr | Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust |
| title_full_unstemmed | Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust |
| title_short | Phlorofucofuroeckol-A: A Natural Compound with Potential to Attenuate Inflammatory Diseases Caused by Airborne Fine Dust |
| title_sort | phlorofucofuroeckol a a natural compound with potential to attenuate inflammatory diseases caused by airborne fine dust |
| topic | fine dust PFF-A inflammation seaweed extract |
| url | https://www.mdpi.com/1648-9144/61/1/165 |
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