Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study
Introduction NNeurite orientation dispersion and density imaging (NODDI) is a new diffusion magnetic resonance imaging technique that can provide specific microstructural evaluation including nervous tissue density, free water fraction, and neurite orientation dispersion. In this study, we explored...
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Termedia Publishing House
2020-04-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Microstructural-changes-in-postoperative-cervical-cords-with-cervical-spondylotic,118578,0,2.html |
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| author | Wen Jiang Xiao Han Guangqi Li Donghang Li Jinchao Wang Hua Guo Xiaoguang Cheng |
| author_facet | Wen Jiang Xiao Han Guangqi Li Donghang Li Jinchao Wang Hua Guo Xiaoguang Cheng |
| author_sort | Wen Jiang |
| collection | DOAJ |
| description | Introduction
NNeurite orientation dispersion and density imaging (NODDI) is a new diffusion magnetic resonance imaging technique that can provide specific microstructural evaluation including nervous tissue density, free water fraction, and neurite orientation dispersion. In this study, we explored the microstructural changes in reduced area (RA) and T2 high signal intensity (T2-HSI) postoperative cervical cords with cervical spondylotic myelopathy (CSM) by NODDI.
Material and methods
A prospective study. CSM patients with surgery planned were recruited in Beijing Jishuitan Hospital from September 2016 to March 2017 (excluding other cervical spondylosis and spinal diseases and postoperative stenosis) and underwent postoperative NODDI scans and modified Japanese Orthopaedic Association (mJOA) scoring. The patients were divided into RA and T2-HSI, normal area (NA) and T2-HSI, and NA and non-T2HSI groups. The differences in NODDI metrics and mJOA score between different groups were assessed respectively.
Results
Nervous tissue density in cervical cords with postoperative constant RA was decreased (RA-T2HSI (0.510, 0.330–0.670) vs. NA-T2HSI (0.585, 0.380–0.870) ( p = 0.019), RA-T2HSI vs. NA-nT2HSI (0.620, 0.460–0.770) ( p = 0.003)), and a certain degree of free water increase and nervous tissue density decline was observed in postoperative cervical cords with T2-HSI, even if not all of the outcomes were very significant. Moreover, the postoperative mJOA score in combined RA and T2-HSI was lower than that in single T2-HSI.
Conclusions
The microstructural changes in postoperative RA and T2-HSI cervical cords could be evaluated by NODDI metrics and RA and T2-HSI were useful as brief evaluations for postoperative CSM cervical cords. |
| format | Article |
| id | doaj-art-b4be504206d44849bc0f3ec604add1cd |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-b4be504206d44849bc0f3ec604add1cd2025-08-20T03:49:32ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512020-04-0121248749310.5114/aoms.2020.94431118578Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary studyWen Jiang0Xiao Han1Guangqi Li2Donghang Li3Jinchao Wang4Hua Guo5Xiaoguang Cheng6Department of Radiology, Beijing Jishuitan Hospital, Beijing, ChinaDepartment of Spine Surgery, Beijing Jishuitan Hospital, Beijing, ChinaCenter for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, ChinaDepartment of Spine Surgery, Beijing Jishuitan Hospital, Beijing, ChinaDepartment of Spine Surgery, Beijing Jishuitan Hospital, Beijing, ChinaCenter for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing, ChinaIntroduction NNeurite orientation dispersion and density imaging (NODDI) is a new diffusion magnetic resonance imaging technique that can provide specific microstructural evaluation including nervous tissue density, free water fraction, and neurite orientation dispersion. In this study, we explored the microstructural changes in reduced area (RA) and T2 high signal intensity (T2-HSI) postoperative cervical cords with cervical spondylotic myelopathy (CSM) by NODDI. Material and methods A prospective study. CSM patients with surgery planned were recruited in Beijing Jishuitan Hospital from September 2016 to March 2017 (excluding other cervical spondylosis and spinal diseases and postoperative stenosis) and underwent postoperative NODDI scans and modified Japanese Orthopaedic Association (mJOA) scoring. The patients were divided into RA and T2-HSI, normal area (NA) and T2-HSI, and NA and non-T2HSI groups. The differences in NODDI metrics and mJOA score between different groups were assessed respectively. Results Nervous tissue density in cervical cords with postoperative constant RA was decreased (RA-T2HSI (0.510, 0.330–0.670) vs. NA-T2HSI (0.585, 0.380–0.870) ( p = 0.019), RA-T2HSI vs. NA-nT2HSI (0.620, 0.460–0.770) ( p = 0.003)), and a certain degree of free water increase and nervous tissue density decline was observed in postoperative cervical cords with T2-HSI, even if not all of the outcomes were very significant. Moreover, the postoperative mJOA score in combined RA and T2-HSI was lower than that in single T2-HSI. Conclusions The microstructural changes in postoperative RA and T2-HSI cervical cords could be evaluated by NODDI metrics and RA and T2-HSI were useful as brief evaluations for postoperative CSM cervical cords.https://www.archivesofmedicalscience.com/Microstructural-changes-in-postoperative-cervical-cords-with-cervical-spondylotic,118578,0,2.htmldegenerative cervical myelopathydiffusion magnetic resonance imagingreduced cross section areat2 high signal intensity |
| spellingShingle | Wen Jiang Xiao Han Guangqi Li Donghang Li Jinchao Wang Hua Guo Xiaoguang Cheng Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study Archives of Medical Science degenerative cervical myelopathy diffusion magnetic resonance imaging reduced cross section area t2 high signal intensity |
| title | Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study |
| title_full | Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study |
| title_fullStr | Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study |
| title_full_unstemmed | Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study |
| title_short | Microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging: a preliminary study |
| title_sort | microstructural changes in postoperative cervical cords with cervical spondylotic myelopathy evaluated by neurite orientation dispersion and density imaging a preliminary study |
| topic | degenerative cervical myelopathy diffusion magnetic resonance imaging reduced cross section area t2 high signal intensity |
| url | https://www.archivesofmedicalscience.com/Microstructural-changes-in-postoperative-cervical-cords-with-cervical-spondylotic,118578,0,2.html |
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