Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in Vitro

The influence of the main antituberculosis drugs (isoniazid, rifampicin, ethambutol) on in vitro apoptosis of peripheral blood lymphocytes from patients with pulmonary tuberculosis was researched. It was shown that all the investigated drugs induced apoptotic death of the lymphocytes in vitro, that...

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Main Authors: O. A. Vasilyeva, V. A. Serebryakova, O. I. Urazova, V. V. Novitsky, T. E. Kononova, I. O. Naslednikova
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2020-05-01
Series:Антибиотики и Химиотерапия
Subjects:
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/342
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author O. A. Vasilyeva
V. A. Serebryakova
O. I. Urazova
V. V. Novitsky
T. E. Kononova
I. O. Naslednikova
author_facet O. A. Vasilyeva
V. A. Serebryakova
O. I. Urazova
V. V. Novitsky
T. E. Kononova
I. O. Naslednikova
author_sort O. A. Vasilyeva
collection DOAJ
description The influence of the main antituberculosis drugs (isoniazid, rifampicin, ethambutol) on in vitro apoptosis of peripheral blood lymphocytes from patients with pulmonary tuberculosis was researched. It was shown that all the investigated drugs induced apoptotic death of the lymphocytes in vitro, that could result in disturbance of antigen-specific response formation in pulmonary tuberculosis.
format Article
id doaj-art-b4bdf67c07c5447181758a55338cb862
institution Kabale University
issn 0235-2990
language Russian
publishDate 2020-05-01
publisher LLC "Publishing House OKI"
record_format Article
series Антибиотики и Химиотерапия
spelling doaj-art-b4bdf67c07c5447181758a55338cb8622025-08-20T03:42:02ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-015511-122529341Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in VitroO. A. Vasilyeva0V. A. Serebryakova1O. I. Urazova2V. V. Novitsky3T. E. Kononova4I. O. Naslednikova5Siberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskSiberian State Medical University, TomskThe influence of the main antituberculosis drugs (isoniazid, rifampicin, ethambutol) on in vitro apoptosis of peripheral blood lymphocytes from patients with pulmonary tuberculosis was researched. It was shown that all the investigated drugs induced apoptotic death of the lymphocytes in vitro, that could result in disturbance of antigen-specific response formation in pulmonary tuberculosis.https://www.antibiotics-chemotherapy.ru/jour/article/view/342isoniazidrifampicinethambutollymphocytes apoptosispulmonary tuberculosis
spellingShingle O. A. Vasilyeva
V. A. Serebryakova
O. I. Urazova
V. V. Novitsky
T. E. Kononova
I. O. Naslednikova
Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in Vitro
Антибиотики и Химиотерапия
isoniazid
rifampicin
ethambutol
lymphocytes apoptosis
pulmonary tuberculosis
title Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in Vitro
title_full Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in Vitro
title_fullStr Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in Vitro
title_full_unstemmed Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in Vitro
title_short Apoptosis-Inducing Action of Antituberculosis Drugs of the Main Group in Vitro
title_sort apoptosis inducing action of antituberculosis drugs of the main group in vitro
topic isoniazid
rifampicin
ethambutol
lymphocytes apoptosis
pulmonary tuberculosis
url https://www.antibiotics-chemotherapy.ru/jour/article/view/342
work_keys_str_mv AT oavasilyeva apoptosisinducingactionofantituberculosisdrugsofthemaingroupinvitro
AT vaserebryakova apoptosisinducingactionofantituberculosisdrugsofthemaingroupinvitro
AT oiurazova apoptosisinducingactionofantituberculosisdrugsofthemaingroupinvitro
AT vvnovitsky apoptosisinducingactionofantituberculosisdrugsofthemaingroupinvitro
AT tekononova apoptosisinducingactionofantituberculosisdrugsofthemaingroupinvitro
AT ionaslednikova apoptosisinducingactionofantituberculosisdrugsofthemaingroupinvitro