The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies
ABSTRACT Background and Aims There are still no useful biomarkers for the prognosis of esophageal squamous cell carcinoma (ESCC). In the prognosis of some kinds of cancer, soluble programmed death 1 (sPD‐1) and programmed death ligand 1 (sPD‐L1) have demonstrated statistical significance, but the pr...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70178 |
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| author | Qiyao Yu Jie Li Wenjie Mao Zheng Li Xuan Li Bin Li |
| author_facet | Qiyao Yu Jie Li Wenjie Mao Zheng Li Xuan Li Bin Li |
| author_sort | Qiyao Yu |
| collection | DOAJ |
| description | ABSTRACT Background and Aims There are still no useful biomarkers for the prognosis of esophageal squamous cell carcinoma (ESCC). In the prognosis of some kinds of cancer, soluble programmed death 1 (sPD‐1) and programmed death ligand 1 (sPD‐L1) have demonstrated statistical significance, but the prognostic value of serum sPD‐L1 and sPD‐1 remains unclear in ESCC. Methods Here, a meta‐analysis was performed to estimate the prognostic value of sPD‐L1 and sPD‐1 in ESCC. To obtain eligible studies, we searched mainstream databases (PubMed, Cochrane, Embase, Web of Science, Wanfang Data, and CNKI), and the survival data including hazard ratios (HR) and its 95% confidence intervals (95% CI) from included literature were extracted. Results Six articles were included, including 645 patients with ESCC. The statistical result of this meta‐analysis indicated that serum sPD‐1 had no significant correlation with overall survival (OS) of patients with ESCC (p > 0.05). Patients with ESCC with high concentrations of serum sPD‐L1 demonstrated a significantly poor prognosis (HR = 1.73, 95% CI: 1.42–2.11, p < 0.001). Conclusion Higher levels of serum sPD‐L1 may predict poor OS in ESCC patients, which may be a promising and credible prognostic biomarker for esophageal cancer. |
| format | Article |
| id | doaj-art-b4bd2cde96e347bd8143412572b8a80e |
| institution | OA Journals |
| issn | 2398-8835 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-b4bd2cde96e347bd8143412572b8a80e2025-08-20T02:05:31ZengWileyHealth Science Reports2398-88352024-11-01711n/an/a10.1002/hsr2.70178The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort StudiesQiyao Yu0Jie Li1Wenjie Mao2Zheng Li3Xuan Li4Bin Li5Department of Plastic Surgery BOE Hospital Chengdu ChinaDepartment of Thoracic Surgery, The Second Hospital & Clinical Medical School Lanzhou University Lanzhou ChinaDepartment of Thoracic Surgery, The Second Hospital & Clinical Medical School Lanzhou University Lanzhou ChinaDepartment of Thoracic Surgery, The Second Hospital & Clinical Medical School Lanzhou University Lanzhou ChinaDepartment of Thoracic Surgery, The Second Hospital & Clinical Medical School Lanzhou University Lanzhou ChinaDepartment of Thoracic Surgery, The Second Hospital & Clinical Medical School Lanzhou University Lanzhou ChinaABSTRACT Background and Aims There are still no useful biomarkers for the prognosis of esophageal squamous cell carcinoma (ESCC). In the prognosis of some kinds of cancer, soluble programmed death 1 (sPD‐1) and programmed death ligand 1 (sPD‐L1) have demonstrated statistical significance, but the prognostic value of serum sPD‐L1 and sPD‐1 remains unclear in ESCC. Methods Here, a meta‐analysis was performed to estimate the prognostic value of sPD‐L1 and sPD‐1 in ESCC. To obtain eligible studies, we searched mainstream databases (PubMed, Cochrane, Embase, Web of Science, Wanfang Data, and CNKI), and the survival data including hazard ratios (HR) and its 95% confidence intervals (95% CI) from included literature were extracted. Results Six articles were included, including 645 patients with ESCC. The statistical result of this meta‐analysis indicated that serum sPD‐1 had no significant correlation with overall survival (OS) of patients with ESCC (p > 0.05). Patients with ESCC with high concentrations of serum sPD‐L1 demonstrated a significantly poor prognosis (HR = 1.73, 95% CI: 1.42–2.11, p < 0.001). Conclusion Higher levels of serum sPD‐L1 may predict poor OS in ESCC patients, which may be a promising and credible prognostic biomarker for esophageal cancer.https://doi.org/10.1002/hsr2.70178biomarkersESCCmeta‐analysisprognosissPD‐1sPD‐L1 |
| spellingShingle | Qiyao Yu Jie Li Wenjie Mao Zheng Li Xuan Li Bin Li The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies Health Science Reports biomarkers ESCC meta‐analysis prognosis sPD‐1 sPD‐L1 |
| title | The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies |
| title_full | The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies |
| title_fullStr | The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies |
| title_full_unstemmed | The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies |
| title_short | The Prognostic Value of Serum Soluble Programmed Death 1 (sPD‐1) and Programmed Death Ligand 1 (sPD‐L1) in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis About Cohort Studies |
| title_sort | prognostic value of serum soluble programmed death 1 spd 1 and programmed death ligand 1 spd l1 in esophageal squamous cell carcinoma a systematic review and meta analysis about cohort studies |
| topic | biomarkers ESCC meta‐analysis prognosis sPD‐1 sPD‐L1 |
| url | https://doi.org/10.1002/hsr2.70178 |
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