Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow.
Active contraction of the diaphragm and other inspiratory pump muscles during swallow create a negative thoracic pressure to improve the movement of the bolus (food/liquid) into the esophagus. We tested the hypothesis that dorsomedial medullary inspiratory neurons, including the nucleus tractus soli...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199903&type=printable |
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| author | Teresa Pitts Ivan Poliacek Melanie J Rose Mitchell D Reed Jillian A Condrey Hsiu-Wen Tsai Guannan Zhou Paul W Davenport Donald C Bolser |
| author_facet | Teresa Pitts Ivan Poliacek Melanie J Rose Mitchell D Reed Jillian A Condrey Hsiu-Wen Tsai Guannan Zhou Paul W Davenport Donald C Bolser |
| author_sort | Teresa Pitts |
| collection | DOAJ |
| description | Active contraction of the diaphragm and other inspiratory pump muscles during swallow create a negative thoracic pressure to improve the movement of the bolus (food/liquid) into the esophagus. We tested the hypothesis that dorsomedial medullary inspiratory neurons, including the nucleus tractus solitarius (NTS, pre-motor to the phrenic) would be active during swallow induced by oral water infusion. We recorded neurons in the NTS and medial reticular formation in anesthetized spontaneously breathing cats, and induced swallow by injection of water into the oropharynx. Our results indicate that: 1) a majority of inspiratory cells in the dorsomedial medulla are active during swallow, 2) expiratory neurons are present in the medial reticular formation (deeper to the NTS) in unparalyzed cats and a majority of these cells decreased firing frequency during swallow. Our findings suggest that the dorsomedial medulla is a source of inspiratory motor drive during swallow and that a novel population of breathing-modulated neurons that also are modulated during swallowing exist in the medial reticular formation in unparalyzed animals. |
| format | Article |
| id | doaj-art-b4ba35b593ae4ee8a44d2a57797d218b |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b4ba35b593ae4ee8a44d2a57797d218b2025-08-20T02:45:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e019990310.1371/journal.pone.0199903Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow.Teresa PittsIvan PoliacekMelanie J RoseMitchell D ReedJillian A CondreyHsiu-Wen TsaiGuannan ZhouPaul W DavenportDonald C BolserActive contraction of the diaphragm and other inspiratory pump muscles during swallow create a negative thoracic pressure to improve the movement of the bolus (food/liquid) into the esophagus. We tested the hypothesis that dorsomedial medullary inspiratory neurons, including the nucleus tractus solitarius (NTS, pre-motor to the phrenic) would be active during swallow induced by oral water infusion. We recorded neurons in the NTS and medial reticular formation in anesthetized spontaneously breathing cats, and induced swallow by injection of water into the oropharynx. Our results indicate that: 1) a majority of inspiratory cells in the dorsomedial medulla are active during swallow, 2) expiratory neurons are present in the medial reticular formation (deeper to the NTS) in unparalyzed cats and a majority of these cells decreased firing frequency during swallow. Our findings suggest that the dorsomedial medulla is a source of inspiratory motor drive during swallow and that a novel population of breathing-modulated neurons that also are modulated during swallowing exist in the medial reticular formation in unparalyzed animals.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199903&type=printable |
| spellingShingle | Teresa Pitts Ivan Poliacek Melanie J Rose Mitchell D Reed Jillian A Condrey Hsiu-Wen Tsai Guannan Zhou Paul W Davenport Donald C Bolser Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow. PLoS ONE |
| title | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow. |
| title_full | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow. |
| title_fullStr | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow. |
| title_full_unstemmed | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow. |
| title_short | Neurons in the dorsomedial medulla contribute to swallow pattern generation: Evidence of inspiratory activity during swallow. |
| title_sort | neurons in the dorsomedial medulla contribute to swallow pattern generation evidence of inspiratory activity during swallow |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199903&type=printable |
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