GLCCI1 alleviates GRP78-initiated endoplasmic reticulum stress-induced apoptosis of retinal ganglion cells in diabetic retinopathy by upregulating and interacting with HSP90AB1

GLCCI1 alleviates GRP78-initiated endoplasmic reticulum stress-induced apoptosis of retinal ganglion cells in diabetic retinopathy by upregulating and interacting with HSP90AB1

Abstract Retinal ganglion cells (RGCs) are among the first neurons to undergo apoptosis in diabetic retinopathy (DR), with their relationship to endoplasmic reticulum stress (ERS)-induced apoptosis still unclear. While glucocorticoid-induced transcript 1 (GLCCI1) has been shown to inhibit apoptosis,...

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Bibliographic Details
Main Authors: Jiayou Liu, Hongdan Yu, Shengxue Yu, Mengren Liu, Xinyuan Chen, Yufei Wang, Jing Li, Caixing Shi, Wenqiang Liu, Zhongfu Zuo, Xuezheng Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
GLCCI1
HSP90AB1
Diabetic retinopathy
Endoplasmic reticulum stress-induced apoptosis
Online Access:https://doi.org/10.1038/s41598-024-75874-4
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