Prognostic Factors and Management Approaches for Small Nonfunctional Pancreatic Neuroendocrine Tumors: Insights from SEER Data
Objective To explore the optimal management strategies for small-sized nonfunctional pancreatic neuroendocrine tumors (NF-PanNETs) and to assess the rationale for the ‘wait and see’ approach.Methods This retrospective study analyzed data from 2,052 patients with small-sized NF-PanNETs (tumor size ≤2...
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| Format: | Article |
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Taylor & Francis Group
2025-07-01
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| Series: | Journal of Investigative Surgery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/08941939.2025.2528340 |
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| author | Haiyi Hu Chuyan Chen Zhibo Zheng Fandong Meng Shutian Zhang Peng Li |
| author_facet | Haiyi Hu Chuyan Chen Zhibo Zheng Fandong Meng Shutian Zhang Peng Li |
| author_sort | Haiyi Hu |
| collection | DOAJ |
| description | Objective To explore the optimal management strategies for small-sized nonfunctional pancreatic neuroendocrine tumors (NF-PanNETs) and to assess the rationale for the ‘wait and see’ approach.Methods This retrospective study analyzed data from 2,052 patients with small-sized NF-PanNETs (tumor size ≤20 mm) diagnosed between 2004 and 2019. Patients were further divided into two groups: those with tumors ≤10 mm (n = 573) and those with tumors 11–20 mm (n = 1,479). Demographic information, clinical characteristics, and survival outcomes were obtained and compared using the Surveillance, Epidemiology, and End Results (SEER) database.Results Tumors ≤10 mm were less likely to exhibit adjacent structure invasion (p = 0.005), lymph node involvement (p = 0.028), or distant metastasis (p < 0.001). Among T1N0M0 patients, both surgery and surveillance yielded similar cancer-specific survival (CSS) for those with tumors ≤10 mm, while surgery was significantly associated with better CSS for patients with tumors in the 11–20 mm range (p = 0.040). Multivariate analyses identified age >65 years, poor differentiation, T4 stage, and M1 stage as independent predictive factors for worse outcomes (all p < 0.001).Conclusions Compared to NF-PanNETs ≤10 mm, tumors sized between 11 and 20 mm are associated with higher risks of adjacent structure invasion, lymph node involvement, and distant metastasis. Tumors ≤10 mm can be safely monitored with active surveillance. |
| format | Article |
| id | doaj-art-b4b8a9a613eb4ffc87aacd05aa41271d |
| institution | DOAJ |
| issn | 0894-1939 1521-0553 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj-art-b4b8a9a613eb4ffc87aacd05aa41271d2025-08-20T03:13:07ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532025-07-0138110.1080/08941939.2025.2528340Prognostic Factors and Management Approaches for Small Nonfunctional Pancreatic Neuroendocrine Tumors: Insights from SEER DataHaiyi Hu0Chuyan Chen1Zhibo Zheng2Fandong Meng3Shutian Zhang4Peng Li5Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, ChinaDepartment of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, ChinaObjective To explore the optimal management strategies for small-sized nonfunctional pancreatic neuroendocrine tumors (NF-PanNETs) and to assess the rationale for the ‘wait and see’ approach.Methods This retrospective study analyzed data from 2,052 patients with small-sized NF-PanNETs (tumor size ≤20 mm) diagnosed between 2004 and 2019. Patients were further divided into two groups: those with tumors ≤10 mm (n = 573) and those with tumors 11–20 mm (n = 1,479). Demographic information, clinical characteristics, and survival outcomes were obtained and compared using the Surveillance, Epidemiology, and End Results (SEER) database.Results Tumors ≤10 mm were less likely to exhibit adjacent structure invasion (p = 0.005), lymph node involvement (p = 0.028), or distant metastasis (p < 0.001). Among T1N0M0 patients, both surgery and surveillance yielded similar cancer-specific survival (CSS) for those with tumors ≤10 mm, while surgery was significantly associated with better CSS for patients with tumors in the 11–20 mm range (p = 0.040). Multivariate analyses identified age >65 years, poor differentiation, T4 stage, and M1 stage as independent predictive factors for worse outcomes (all p < 0.001).Conclusions Compared to NF-PanNETs ≤10 mm, tumors sized between 11 and 20 mm are associated with higher risks of adjacent structure invasion, lymph node involvement, and distant metastasis. Tumors ≤10 mm can be safely monitored with active surveillance.https://www.tandfonline.com/doi/10.1080/08941939.2025.2528340pancreatic neuroendocrine tumorstumor sizepredictive factorsprognosissurveillance |
| spellingShingle | Haiyi Hu Chuyan Chen Zhibo Zheng Fandong Meng Shutian Zhang Peng Li Prognostic Factors and Management Approaches for Small Nonfunctional Pancreatic Neuroendocrine Tumors: Insights from SEER Data Journal of Investigative Surgery pancreatic neuroendocrine tumors tumor size predictive factors prognosis surveillance |
| title | Prognostic Factors and Management Approaches for Small Nonfunctional Pancreatic Neuroendocrine Tumors: Insights from SEER Data |
| title_full | Prognostic Factors and Management Approaches for Small Nonfunctional Pancreatic Neuroendocrine Tumors: Insights from SEER Data |
| title_fullStr | Prognostic Factors and Management Approaches for Small Nonfunctional Pancreatic Neuroendocrine Tumors: Insights from SEER Data |
| title_full_unstemmed | Prognostic Factors and Management Approaches for Small Nonfunctional Pancreatic Neuroendocrine Tumors: Insights from SEER Data |
| title_short | Prognostic Factors and Management Approaches for Small Nonfunctional Pancreatic Neuroendocrine Tumors: Insights from SEER Data |
| title_sort | prognostic factors and management approaches for small nonfunctional pancreatic neuroendocrine tumors insights from seer data |
| topic | pancreatic neuroendocrine tumors tumor size predictive factors prognosis surveillance |
| url | https://www.tandfonline.com/doi/10.1080/08941939.2025.2528340 |
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