Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts

Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts

1,2,4-Triazole derivatives are successfully used in medicine as antibacterial and antifungal agents. Aim of our research is the study of synthesis of 7'-((3-thio-4-ethyl-4H-1,2,4-triazole-5-yl)methyl)-3'-methylxanthine. Methods and results. Sodium salt of 3-methylxanthine has been us...

Full description

Saved in:

Bibliographic Details
Main Author:	A. S. Gotsulya
Format:	Article
Language:	English
Published:	Zaporizhzhia State Medical and Pharmaceutical University 2016-04-01
Series:	Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:	xanthines xanthines; 1 2 4-triazole physical and chemical properties 1 2 4-triazole
Online Access:	http://pharmed.zsmu.edu.ua/article/view/62003/58034
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effect of 4-benzylidenamino-5-phenyl-4Н-1,2,4-triazole-3-thiones and salts of 2-(4-amino-5-phenyl-4Н-1,2,4-triazole-3-ylthio)acetic acid on central component of nociceptive system
by: Ye. S. Pruhlo
Published: (2016-08-01)

Analgesic activity of the salts of 2-(5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-ylthio)acetic acid
by: V. M. Odintsova
Published: (2016-04-01)

Synthesis and investigation of the physical-chemical properties of 2-(5-((theophylline-7'-yl)methyl)-4-methyl-4H-1,2,4-triazole-3-ylthio)acetic acid salts
by: A. S. Gotsulya
Published: (2016-12-01)

Acute toxicity of 2-(5-(adamantane-1-yl)-4R-1,2,4-triazole-3-ylthio) of the acetic acids and their salts’ derivatives
by: V. M. Odyntsova, et al.
Published: (2015-12-01)

Synthesis and antituberculosis activity of N'-(2-(5-((theophylline-7'-yl)methyl)-4-R-4Н-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazides
by: A. S. Gotsulya, et al.
Published: (2018-08-01)

Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines
by: Ye. O. Karpun, et al.
Published: (2020-11-01)

The study of analgesic effect of 5-(furan-2-yl, 2-methylfuran-3-yl)-4-amino-1,2,4-triazole-3-thion derivatives
by: D. M. Danilchenko
Published: (2018-10-01)

Synthesis and physical-chemical properties of 2-((4-R-3-(morpholinomethylen)-4H-1,2,4-triazole-5yl)thio)acetic acid
by: R. О. Shcherbyna, et al.
Published: (2014-12-01)

Sodium 2-(4-amino-(5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate, synthesis, study of biochemical indicators of blood serum cows in its use
by: D. M. Danilchenko, et al.
Published: (2017-04-01)

Synthesis and physical-chemical properties of 3-(4-(tert-butyl)phenyl)-5-(R-ylthio)-4H-1,2,4-triazol-4-amines
by: I. I. Aksyonova, et al.
Published: (2016-04-01)

Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones
by: Ye. S. Pruglo, et al.
Published: (2015-12-01)

Synthesis, physical-chemical properties of 2-((5-(adamantan-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)acetic acid esters
by: V. M. Odyntsova
Published: (2017-04-01)

ACUTE TOXICITYOF 4-AMINO-5-(2-, 3-, 4-NITROPHENYL)-1,2,4-TRIAZOLE-3-THIONES AND ITS DERIVATIVES
by: М. O. Shcherbak, et al.
Published: (2014-12-01)

The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols
by: Ye. O. Karpun, et al.
Published: (2022-08-01)

Synthesis, structure and properties of N-R-2-(5-(5-methyl-1H-pyrazole-3-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetamides
by: A. S. Hotsulia, et al.
Published: (2019-03-01)

Actoprotective properties of 7'-((3-thio-4-methyl-4H-1,2,4-triazole-5-yl)methyl)theophylline derivatives
by: A. S. Gotsulya
Published: (2016-06-01)

Synthesis, physical-chemical properties and further transformation of 5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dyhydro-3Н-1,2,4-triazole-3-thiones
by: T. M. Kaplaushenko
Published: (2016-08-01)

Comparative pharmacokinetic study of dosage forms with morpholinium 2-[5-(pyridin-4-yl)-1,2,4-triazol-3-ylthio] acetate
by: I. V. Bushueva, et al.
Published: (2014-12-01)

Synthesis and properties of S-alkyl 4-amino-5-(5-(3-fluorophenyl)-pyrazol-3-yl)-1,2,4-triazole-3-thiol derivatives
by: S. O. Fedotov, et al.
Published: (2023-04-01)

Synthesis, structure and properties of N-R-amides and hydrazides of 2-[4-R-5-(theophylline-7ʹ-yl)-1,2,4-triazole-3-ylthio]acetic acid
by: A. S. Gotsulya
Published: (2017-12-01)

DFT analysis of the [3 + 2] heterocyclization reaction of ((1,2,4-triazole(1,3,4-oxadiazole)-3(2)-yl)methyl)thiopyrimidines
by: Yu. V. Karpenko
Published: (2025-03-01)

Analgesic activity of 4-amino-5-methyl-4H-1,2,4-triazol-3-thiones
by: T. V. Kravchenko, et al.
Published: (2018-10-01)

Computer prediction of acute toxicity of thioderivatives of 3,5-bis(5-mercapto-4-R-4H-1,2,4-triazol-3-yl)phenol
by: K. K. Isaicheva, et al.
Published: (2024-11-01)

Synthesis and structure of salts of 2-(((3-mercapto-5-methyl-4H-1,2,4-triazole-4-yl)imino)methyl)benzoic acid
by: T. V. Hlazunova
Published: (2020-05-01)

Creation, study of physical and chemical properties of 2-((4-R-5-phenethyl-4H-1,2,4-triazole-3-yl)thio)ethanоic(propanоic, benzoic)acids and salts of 2-((4-R-5-phenethyl-4H-1,2,4-triazole-3-yl)thio)ethanoic acid
by: T. V. Ihnatova, et al.
Published: (2019-07-01)

Antidepressant activity of 4-amino-5-(alkyl-, aryl-, heteryl)-1,2,4-triazole-3-thione benzylidene derivatives
by: Ye. S. Pruhlo
Published: (2018-10-01)

Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives
by: Yu. G. Samelyuk, et al.
Published: (2015-12-01)

Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides
by: O. A. Suhak, et al.
Published: (2017-04-01)

Synthesis methods of 1,2,4-triazole-3-thiones: review
by: Yu. S. Frolova, et al.
Published: (2024-06-01)

Synthesis and properties of S-derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol
by: S. O. Fedotov, et al.
Published: (2021-12-01)

Search for antibacterial activity in a number of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines
by: Yu. V. Karpenko, et al.
Published: (2021-07-01)

Synthesis, physical and chemical research of alkyl-, heterylderivatives of 7'-((4-ethyl-5-thio-4H-1,2,4-triazoles-3-yl)methyl)theophylline
by: A. S. Gotsulya
Published: (2016-08-01)

Actoprotective activity research of 2-((5-(2-bromophenyl)-4-substituted-4H-1,2,4-triazole-3-yl)thio)acetates
by: A. A. Safonov, et al.
Published: (2020-09-01)

Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation
by: Rezki Nadjet, et al.
Published: (2017-09-01)

Synthesis and properties of 5-(((5-amino-1,3,4-thiadiazole-2-yl)thio)methyl)-4-phenyl-1,2,4-triazole-3-thione and its some S-derivatives
by: A. S. Hotsulia, et al.
Published: (2020-08-01)

Anticonvulsant activity 2-((5-(3-(4-fluorophenyl)-4-R2-1,2,4-triazole-3-yl)-thio)-1-arylethanone
by: O. A. Bihdan
Published: (2019-12-01)

Synthesis, structure and properties of 7-((4-amino-5-thio-1,2,4-triazole-3-yl)methyl)-theophylline derivatives
by: A. S. Hotsulia, et al.
Published: (2020-08-01)

Antimicrobial and antifungal activity of some (5-(adamantane-1-yl)-4R-1,2,4-triazole-3-ylthiols substitutes
by: V. M. Odyntsova
Published: (2016-12-01)

Absorption of Free Radicals of New S-Derivatives (1,2,4-Triazole-3(2<i>H</i>)-yl)methyl)thiopyrimidines
by: Yuriy Karpenko
Published: (2024-11-01)

In silico study of biological activity of 2-[5-(furan-2-yl)-4-phenyl-4n-1,2,4-triazol-3-ylthio]-1-(4-chlorophenylethanone)
by: N. M. Borysenko, et al.
Published: (2025-06-01)