Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts
1,2,4-Triazole derivatives are successfully used in medicine as antibacterial and antifungal agents. Aim of our research is the study of synthesis of 7'-((3-thio-4-ethyl-4H-1,2,4-triazole-5-yl)methyl)-3'-methylxanthine. Methods and results. Sodium salt of 3-methylxanthine has been us...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2016-04-01
|
| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| Subjects: | |
| Online Access: | http://pharmed.zsmu.edu.ua/article/view/62003/58034 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849398129297719296 |
|---|---|
| author | A. S. Gotsulya |
| author_facet | A. S. Gotsulya |
| author_sort | A. S. Gotsulya |
| collection | DOAJ |
| description | 1,2,4-Triazole derivatives are successfully used in medicine as antibacterial and antifungal agents.
Aim of our research is the study of synthesis of 7'-((3-thio-4-ethyl-4H-1,2,4-triazole-5-yl)methyl)-3'-methylxanthine.
Methods and results. Sodium salt of 3-methylxanthine has been used as the initial substance to obtain a new series of these compounds. It has been shown that the reaction of the corresponding hydrazide interaction with ethylisothiocyanate finds its continuation in the intramolecular cyclization. The synthesis of 2-(4-ethyl-5-((3'-methylxantine-7'-yl)methyl)-4Н-1,2,4-triazol-3-ylthio)аcetic acid’s salts has been performed. Physical-chemical properties of compounds have been researched and their structure and individuality has been confirmed by elemental analysis, IR-spectroscopy, 1H NMR-spectroscopy, chromato-mass and mass-spectrometry.
Conclusion. 12 New compounds have been obtained and their structure has been confirmed. |
| format | Article |
| id | doaj-art-b4af91ea22cc497e8f257a5706ef719b |
| institution | Kabale University |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2016-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-b4af91ea22cc497e8f257a5706ef719b2025-08-20T03:38:43ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322016-04-0114710.14739/2409-2932.2016.1.62003Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s saltsA. S. Gotsulya1,2,4-Triazole derivatives are successfully used in medicine as antibacterial and antifungal agents. Aim of our research is the study of synthesis of 7'-((3-thio-4-ethyl-4H-1,2,4-triazole-5-yl)methyl)-3'-methylxanthine. Methods and results. Sodium salt of 3-methylxanthine has been used as the initial substance to obtain a new series of these compounds. It has been shown that the reaction of the corresponding hydrazide interaction with ethylisothiocyanate finds its continuation in the intramolecular cyclization. The synthesis of 2-(4-ethyl-5-((3'-methylxantine-7'-yl)methyl)-4Н-1,2,4-triazol-3-ylthio)аcetic acid’s salts has been performed. Physical-chemical properties of compounds have been researched and their structure and individuality has been confirmed by elemental analysis, IR-spectroscopy, 1H NMR-spectroscopy, chromato-mass and mass-spectrometry. Conclusion. 12 New compounds have been obtained and their structure has been confirmed.http://pharmed.zsmu.edu.ua/article/view/62003/58034xanthinesxanthines; 1 2 4-triazolephysical and chemical properties1 2 4-triazole |
| spellingShingle | A. S. Gotsulya Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki xanthines xanthines; 1 2 4-triazole physical and chemical properties 1 2 4-triazole |
| title | Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts |
| title_full | Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts |
| title_fullStr | Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts |
| title_full_unstemmed | Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts |
| title_short | Synthesis and research on properties of 2-(4-еthyl-5-((3'-methylxantine-7'-yl)methyl)-4H-1,2,4-triazole-3-ylthio)acetic acid’s salts |
| title_sort | synthesis and research on properties of 2 4 еthyl 5 3 methylxantine 7 yl methyl 4h 1 2 4 triazole 3 ylthio acetic acid s salts |
| topic | xanthines xanthines; 1 2 4-triazole physical and chemical properties 1 2 4-triazole |
| url | http://pharmed.zsmu.edu.ua/article/view/62003/58034 |
| work_keys_str_mv | AT asgotsulya synthesisandresearchonpropertiesof24ethyl53methylxantine7ylmethyl4h124triazole3ylthioaceticacidssalts |