Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signalling in murine ileitis
Abstract Crohn’s disease (CD) is a persistent inflammatory disorder primarily affecting the terminal ileum. The Tnf ΔΑRE mice, which spontaneously develop CD-like ileitis due to TNF overexpression, represent a faithful model of the human disease. Here, via single-cell RNA sequencing in Tnf ΔΑRE mice...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-57570-7 |
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