Clinical efficacy of sacubitril/valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction: a single-center randomized trial
Abstract Objective To investigate the effect of sacubitril/valsartan (ARNI) combined with cardiac rehabilitation (CR) in patients with heart failure (HF) after acute myocardial infarction (AMI). Methods A total of 118 patients with HF after AMI were screened and randomly divided into an experimental...
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BMC
2025-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04682-z |
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| author | Yan-Mei Zhao Jun-Ting Luo Kai-Fang Pang Ying Feng Jian-Ping Tan Ming Liu Zhi-Hai Lin |
| author_facet | Yan-Mei Zhao Jun-Ting Luo Kai-Fang Pang Ying Feng Jian-Ping Tan Ming Liu Zhi-Hai Lin |
| author_sort | Yan-Mei Zhao |
| collection | DOAJ |
| description | Abstract Objective To investigate the effect of sacubitril/valsartan (ARNI) combined with cardiac rehabilitation (CR) in patients with heart failure (HF) after acute myocardial infarction (AMI). Methods A total of 118 patients with HF after AMI were screened and randomly divided into an experimental group and a control group. The control group was given ARNI. The experimental group received CR treatment in addition to the control treatment. The primary endpoint was cardiorespiratory fitness as measured by the cardiopulmonary exercise test (CPET). The secondary endpoints included cardiac remodeling detected by NT-ProBNP and cardiac ultrasound. All participants were assessed by CPET, NT-ProBNP, and cardiac ultrasound at baseline and after treatment. Results After treatment, the changes in the left ventricular ejection fraction (LVEF), anaerobic threshold (AT), oxygen uptake peak (VO2 peak), and metabolic equivalents (METs) in the experimental group were significantly greater than those in the control group (all P < 0.05). However, there was no significant difference in BNP, Left atrial diameter (LA) or Left ventricular end diastolic diameter (LVD) between the two groups (P > 0.05). Conclusions Patients with HF after AMI could benefit from combined ARNI and CR. Trial registration http://www.chictr.org.cn , ChiCTR2400093772 (11/12/2024). Retrospectively registered. |
| format | Article |
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| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-b4aaf2ceb3d9499e8085aefc5826713b2025-08-20T03:04:59ZengBMCBMC Cardiovascular Disorders1471-22612025-04-012511810.1186/s12872-025-04682-zClinical efficacy of sacubitril/valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction: a single-center randomized trialYan-Mei Zhao0Jun-Ting Luo1Kai-Fang Pang2Ying Feng3Jian-Ping Tan4Ming Liu5Zhi-Hai Lin6Department of Cardiology, The Sixth Affiliated Hospital of Guangxi Medical University (Yulin First People’s Hospital)Department of Cardiology, The Sixth Affiliated Hospital of Guangxi Medical University (Yulin First People’s Hospital)Department of Cardiology, The Sixth Affiliated Hospital of Guangxi Medical University (Yulin First People’s Hospital)Department of Cardiology, The Sixth Affiliated Hospital of Guangxi Medical University (Yulin First People’s Hospital)Department of Cardiology, The Sixth Affiliated Hospital of Guangxi Medical University (Yulin First People’s Hospital)Department of Cardiology, The Sixth Affiliated Hospital of Guangxi Medical University (Yulin First People’s Hospital)Department of Cardiology, The Sixth Affiliated Hospital of Guangxi Medical University (Yulin First People’s Hospital)Abstract Objective To investigate the effect of sacubitril/valsartan (ARNI) combined with cardiac rehabilitation (CR) in patients with heart failure (HF) after acute myocardial infarction (AMI). Methods A total of 118 patients with HF after AMI were screened and randomly divided into an experimental group and a control group. The control group was given ARNI. The experimental group received CR treatment in addition to the control treatment. The primary endpoint was cardiorespiratory fitness as measured by the cardiopulmonary exercise test (CPET). The secondary endpoints included cardiac remodeling detected by NT-ProBNP and cardiac ultrasound. All participants were assessed by CPET, NT-ProBNP, and cardiac ultrasound at baseline and after treatment. Results After treatment, the changes in the left ventricular ejection fraction (LVEF), anaerobic threshold (AT), oxygen uptake peak (VO2 peak), and metabolic equivalents (METs) in the experimental group were significantly greater than those in the control group (all P < 0.05). However, there was no significant difference in BNP, Left atrial diameter (LA) or Left ventricular end diastolic diameter (LVD) between the two groups (P > 0.05). Conclusions Patients with HF after AMI could benefit from combined ARNI and CR. Trial registration http://www.chictr.org.cn , ChiCTR2400093772 (11/12/2024). Retrospectively registered.https://doi.org/10.1186/s12872-025-04682-zCardiac rehabilitationSacubitril/valsartanAcute myocardial infarctionHeart failure |
| spellingShingle | Yan-Mei Zhao Jun-Ting Luo Kai-Fang Pang Ying Feng Jian-Ping Tan Ming Liu Zhi-Hai Lin Clinical efficacy of sacubitril/valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction: a single-center randomized trial BMC Cardiovascular Disorders Cardiac rehabilitation Sacubitril/valsartan Acute myocardial infarction Heart failure |
| title | Clinical efficacy of sacubitril/valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction: a single-center randomized trial |
| title_full | Clinical efficacy of sacubitril/valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction: a single-center randomized trial |
| title_fullStr | Clinical efficacy of sacubitril/valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction: a single-center randomized trial |
| title_full_unstemmed | Clinical efficacy of sacubitril/valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction: a single-center randomized trial |
| title_short | Clinical efficacy of sacubitril/valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction: a single-center randomized trial |
| title_sort | clinical efficacy of sacubitril valsartan combined with cardiac rehabilitation in patients with heart failure after acute myocardial infarction a single center randomized trial |
| topic | Cardiac rehabilitation Sacubitril/valsartan Acute myocardial infarction Heart failure |
| url | https://doi.org/10.1186/s12872-025-04682-z |
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