An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations
Asthma is a reversible clinical condition characterized by airway obstruction due to bronchial smooth muscle contraction, inflammation and a hypersecretive state. Severe asthma exacerbations (SAE) may be a part of the natural history of this condition. Patients presenting with SAE are at higher risk...
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| Format: | Article |
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MDPI AG
2025-02-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/61/2/328 |
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| author | Giuseppe Cuttone Luigi La Via Federico Pappalardo Massimiliano Sorbello Daniele Salvatore Paternò Matteo Piattoli Cesare Gregoretti Giovanni Misseri |
| author_facet | Giuseppe Cuttone Luigi La Via Federico Pappalardo Massimiliano Sorbello Daniele Salvatore Paternò Matteo Piattoli Cesare Gregoretti Giovanni Misseri |
| author_sort | Giuseppe Cuttone |
| collection | DOAJ |
| description | Asthma is a reversible clinical condition characterized by airway obstruction due to bronchial smooth muscle contraction, inflammation and a hypersecretive state. Severe asthma exacerbations (SAE) may be a part of the natural history of this condition. Patients presenting with SAE are at higher risk of recurrent attacks, often nonresponsive to medical therapy and eventually requiring invasive mechanical ventilation (MV). The use of noninvasive respiratory supports (NRSs) may be beneficial in patients with SAE who are at risk of developing acute respiratory failure (ARF). However, their application is insufficiently supported by the evidence, as reports on their application in asthmatic patients are scarce and only a few retrospective studies with a limited number of participants have been published to date. This review discusses the potentialities of NRS in the treatment of SAE, with reference to the pathophysiological background and future perspectives on their use in asthma management. |
| format | Article |
| id | doaj-art-b4a9c8cf00e24cedbbcdb618d148b1fc |
| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-b4a9c8cf00e24cedbbcdb618d148b1fc2025-08-20T02:03:40ZengMDPI AGMedicina1010-660X1648-91442025-02-0161232810.3390/medicina61020328An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma ExacerbationsGiuseppe Cuttone0Luigi La Via1Federico Pappalardo2Massimiliano Sorbello3Daniele Salvatore Paternò4Matteo Piattoli5Cesare Gregoretti6Giovanni Misseri7Department of Anaesthesia and Trauma Center, Azienda Ospedaliera “Ospedali Riuniti Villa Sofia–Cervello”, 90146 Palermo, ItalyDepartment of Anaesthesia and Intensive Care 1, University Hospital Policlinico “G. Rodolico–San Marco”, 95123 Catania, ItalyFaculty of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyFaculty of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Anaesthesia and Intensive Care, Giovanni Paolo II Hospital, 97100 Ragusa, ItalyFaculty of Medicine and Dentistry, Università degli Studi di Roma “La Sapienza”, 00185 Rome, ItalyFaculty of Medicine and Surgery, Saint Camillus International University of Health and Medical Sciences “UniCamillus”, 00131 Rome, ItalyDepartment of Anaesthesia and Intensive Care, Fondazione Istituto “G. Giglio” Cefalù, 90015 Palermo, ItalyAsthma is a reversible clinical condition characterized by airway obstruction due to bronchial smooth muscle contraction, inflammation and a hypersecretive state. Severe asthma exacerbations (SAE) may be a part of the natural history of this condition. Patients presenting with SAE are at higher risk of recurrent attacks, often nonresponsive to medical therapy and eventually requiring invasive mechanical ventilation (MV). The use of noninvasive respiratory supports (NRSs) may be beneficial in patients with SAE who are at risk of developing acute respiratory failure (ARF). However, their application is insufficiently supported by the evidence, as reports on their application in asthmatic patients are scarce and only a few retrospective studies with a limited number of participants have been published to date. This review discusses the potentialities of NRS in the treatment of SAE, with reference to the pathophysiological background and future perspectives on their use in asthma management.https://www.mdpi.com/1648-9144/61/2/328acute respiratory failureARFasthmaCPAPhigh flow nasal cannulaHFNOT |
| spellingShingle | Giuseppe Cuttone Luigi La Via Federico Pappalardo Massimiliano Sorbello Daniele Salvatore Paternò Matteo Piattoli Cesare Gregoretti Giovanni Misseri An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations Medicina acute respiratory failure ARF asthma CPAP high flow nasal cannula HFNOT |
| title | An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations |
| title_full | An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations |
| title_fullStr | An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations |
| title_full_unstemmed | An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations |
| title_short | An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations |
| title_sort | updated review on the use of noninvasive respiratory supports in the management of severe asthma exacerbations |
| topic | acute respiratory failure ARF asthma CPAP high flow nasal cannula HFNOT |
| url | https://www.mdpi.com/1648-9144/61/2/328 |
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