From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males

Anti-Müllerian hormone (AMH), a biomarker secreted by Sertoli cells in the testes, has emerged as a critical indicator of male reproductive function with significant clinical application potential. AMH reflects Sertoli cell activity and plays a pivotal role across different stages of male gonadal fu...

Full description

Saved in:
Bibliographic Details
Main Authors: Yuanyuan Zeng, Guicheng Zhao, Yi Zheng, Xiaohui Jiang
Format: Article
Language:English
Published: Bioscientifica 2025-01-01
Series:Endocrine Connections
Subjects:
Online Access:https://ec.bioscientifica.com/view/journals/ec/14/3/EC-24-0630.xml
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832539706549600256
author Yuanyuan Zeng
Guicheng Zhao
Yi Zheng
Xiaohui Jiang
author_facet Yuanyuan Zeng
Guicheng Zhao
Yi Zheng
Xiaohui Jiang
author_sort Yuanyuan Zeng
collection DOAJ
description Anti-Müllerian hormone (AMH), a biomarker secreted by Sertoli cells in the testes, has emerged as a critical indicator of male reproductive function with significant clinical application potential. AMH reflects Sertoli cell activity and plays a pivotal role across different stages of male gonadal function. First, in prepubertal males, AMH levels are crucial for assessing testicular development and the progression of puberty, with delayed or insufficient AMH secretion often being associated with disorders such as delayed puberty. Second, in reproductive-age males, AMH serves as an important biomarker for evaluating spermatogenic capacity, particularly in cases of idiopathic non-obstructive azoospermia. In these patients, AMH levels can help predict the success of testicular sperm extraction, thereby influencing fertility treatment strategies. This review explores the physiological mechanisms of AMH and its diagnostic and prognostic significance in both delayed puberty and fertility disorders in reproductive-age males. While AMH shows great promise in the management of hypogonadism, further research is needed to validate its clinical utility and refine treatment protocols for optimizing patient outcomes.
format Article
id doaj-art-b4a695054c134ee4a5cb04d42b935eb5
institution Kabale University
issn 2049-3614
language English
publishDate 2025-01-01
publisher Bioscientifica
record_format Article
series Endocrine Connections
spelling doaj-art-b4a695054c134ee4a5cb04d42b935eb52025-02-05T10:16:05ZengBioscientificaEndocrine Connections2049-36142025-01-0114310.1530/EC-24-06301From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in malesYuanyuan Zeng0Guicheng Zhao1Yi Zheng2Xiaohui Jiang3Human Sperm Bank, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, ChinaHuman Sperm Bank, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, ChinaHuman Sperm Bank, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, ChinaHuman Sperm Bank, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, ChinaAnti-Müllerian hormone (AMH), a biomarker secreted by Sertoli cells in the testes, has emerged as a critical indicator of male reproductive function with significant clinical application potential. AMH reflects Sertoli cell activity and plays a pivotal role across different stages of male gonadal function. First, in prepubertal males, AMH levels are crucial for assessing testicular development and the progression of puberty, with delayed or insufficient AMH secretion often being associated with disorders such as delayed puberty. Second, in reproductive-age males, AMH serves as an important biomarker for evaluating spermatogenic capacity, particularly in cases of idiopathic non-obstructive azoospermia. In these patients, AMH levels can help predict the success of testicular sperm extraction, thereby influencing fertility treatment strategies. This review explores the physiological mechanisms of AMH and its diagnostic and prognostic significance in both delayed puberty and fertility disorders in reproductive-age males. While AMH shows great promise in the management of hypogonadism, further research is needed to validate its clinical utility and refine treatment protocols for optimizing patient outcomes.https://ec.bioscientifica.com/view/journals/ec/14/3/EC-24-0630.xmlamhhypogonadismdelayed pubertyinoabtb
spellingShingle Yuanyuan Zeng
Guicheng Zhao
Yi Zheng
Xiaohui Jiang
From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males
Endocrine Connections
amh
hypogonadism
delayed puberty
inoa
btb
title From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males
title_full From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males
title_fullStr From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males
title_full_unstemmed From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males
title_short From biological marker to clinical application: the role of anti-Müllerian hormone for delayed puberty and idiopathic non-obstructive azoospermia in males
title_sort from biological marker to clinical application the role of anti mullerian hormone for delayed puberty and idiopathic non obstructive azoospermia in males
topic amh
hypogonadism
delayed puberty
inoa
btb
url https://ec.bioscientifica.com/view/journals/ec/14/3/EC-24-0630.xml
work_keys_str_mv AT yuanyuanzeng frombiologicalmarkertoclinicalapplicationtheroleofantimullerianhormonefordelayedpubertyandidiopathicnonobstructiveazoospermiainmales
AT guichengzhao frombiologicalmarkertoclinicalapplicationtheroleofantimullerianhormonefordelayedpubertyandidiopathicnonobstructiveazoospermiainmales
AT yizheng frombiologicalmarkertoclinicalapplicationtheroleofantimullerianhormonefordelayedpubertyandidiopathicnonobstructiveazoospermiainmales
AT xiaohuijiang frombiologicalmarkertoclinicalapplicationtheroleofantimullerianhormonefordelayedpubertyandidiopathicnonobstructiveazoospermiainmales