Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC)
Oxidative stress resulted to decrease in cells viability compared to the control (78 ± 5 % and 100 ± 6 %, respectively, р < 0,05). GK-2 and NGF prevented H2O2-induced HUVEC cells damages (95 ± 3 % for HA-2 and 97 ± 4 % for NGF vs. 78 ± 5 % for H2O2, p < 0.05). In control the number of cells wi...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2019-01-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/82 |
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| author | T. A. Antipova S. V. Nikolaev S. A. Kryzhanovsky E. S. Pekeldina |
| author_facet | T. A. Antipova S. V. Nikolaev S. A. Kryzhanovsky E. S. Pekeldina |
| author_sort | T. A. Antipova |
| collection | DOAJ |
| description | Oxidative stress resulted to decrease in cells viability compared to the control (78 ± 5 % and 100 ± 6 %, respectively, р < 0,05). GK-2 and NGF prevented H2O2-induced HUVEC cells damages (95 ± 3 % for HA-2 and 97 ± 4 % for NGF vs. 78 ± 5 % for H2O2, p < 0.05). In control the number of cells with condensed chromatin was 9 ± 2, after the addition of H2O2 78 ± 9 (p < 0.05 compared with the control). The addition of NGF or GK-2 after H2O2 significantly reduced the number of such cells (44 ± 9 and 41 ± 8, respectively) (p < 0.05 compared to hydrogen peroxide) and prevented the development of morphological changes in nuclear chromatin. Thus GK-2, like NGF, in human endothelial cell culture HUVEC prevented the apoptosis development caused by hydrogen peroxide. |
| format | Article |
| id | doaj-art-b4a3bbbdd58542a9abc034b9a4a241a9 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-b4a3bbbdd58542a9abc034b9a4a241a92025-08-20T03:42:31ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302019-01-0101182110.24411/2587-7836-2019-1003581Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC)T. A. Antipova0S. V. Nikolaev1S. A. Kryzhanovsky2E. S. Pekeldina3FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»Oxidative stress resulted to decrease in cells viability compared to the control (78 ± 5 % and 100 ± 6 %, respectively, р < 0,05). GK-2 and NGF prevented H2O2-induced HUVEC cells damages (95 ± 3 % for HA-2 and 97 ± 4 % for NGF vs. 78 ± 5 % for H2O2, p < 0.05). In control the number of cells with condensed chromatin was 9 ± 2, after the addition of H2O2 78 ± 9 (p < 0.05 compared with the control). The addition of NGF or GK-2 after H2O2 significantly reduced the number of such cells (44 ± 9 and 41 ± 8, respectively) (p < 0.05 compared to hydrogen peroxide) and prevented the development of morphological changes in nuclear chromatin. Thus GK-2, like NGF, in human endothelial cell culture HUVEC prevented the apoptosis development caused by hydrogen peroxide.https://www.pharmacokinetica.ru/jour/article/view/82ngfдимерный дипептидный миметик гк-2huvec клетки эндотелия человекаокислительный стрессапоптозngfdimeric dipeptide mimetic gk-2huvecoxidative stressapoptosis |
| spellingShingle | T. A. Antipova S. V. Nikolaev S. A. Kryzhanovsky E. S. Pekeldina Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC) Фармакокинетика и Фармакодинамика ngf димерный дипептидный миметик гк-2 huvec клетки эндотелия человека окислительный стресс апоптоз ngf dimeric dipeptide mimetic gk-2 huvec oxidative stress apoptosis |
| title | Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC) |
| title_full | Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC) |
| title_fullStr | Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC) |
| title_full_unstemmed | Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC) |
| title_short | Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC) |
| title_sort | research of neuroprotective properties of trka receptor agonist gk 2 on model of oxidative stress in human vascular endothelial cells huvec |
| topic | ngf димерный дипептидный миметик гк-2 huvec клетки эндотелия человека окислительный стресс апоптоз ngf dimeric dipeptide mimetic gk-2 huvec oxidative stress apoptosis |
| url | https://www.pharmacokinetica.ru/jour/article/view/82 |
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