Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis B
Abstract Chronic hepatitis B (CHB) patients who have sustained virological suppression (SVS) still develop hepatocellular carcinoma(HCC), and the risk factors for developing HCC in these patients are not fully understood. This study included a total of 5234 patients who achieved SVS. After SVS, the...
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| Language: | English |
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BMC
2025-04-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-14015-0 |
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| author | Jianna Zhang Zhiqiang Lan Kailu Zhu Sijie Yu Shibo Li Yu Huang |
| author_facet | Jianna Zhang Zhiqiang Lan Kailu Zhu Sijie Yu Shibo Li Yu Huang |
| author_sort | Jianna Zhang |
| collection | DOAJ |
| description | Abstract Chronic hepatitis B (CHB) patients who have sustained virological suppression (SVS) still develop hepatocellular carcinoma(HCC), and the risk factors for developing HCC in these patients are not fully understood. This study included a total of 5234 patients who achieved SVS. After SVS, the incidence rate of HCC was 1.9% in 1–8 years and 1.33% in 9–16 years. There was a significant difference between the two periods (P < 0.001). After 1–8 years and 9–16 years of SVS, after multivariate analysis and IPTW adjustment, the factors related to the occurrence of HCC were men, hypertensive patients, diabetes patients and high FIB-4 scores. In summary, patients with CHB who have achieved SVS may still develop HCC. Among them, men, hypertensive patients, diabetes patients and high FIB-4 scores should be listed as the key monitoring objects of HCC. Clinical trial number: Not applicable. |
| format | Article |
| id | doaj-art-b4a337d046304f6b94fef9fcbca3cf53 |
| institution | OA Journals |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-b4a337d046304f6b94fef9fcbca3cf532025-08-20T02:17:09ZengBMCBMC Cancer1471-24072025-04-0125111210.1186/s12885-025-14015-0Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis BJianna Zhang0Zhiqiang Lan1Kailu Zhu2Sijie Yu3Shibo Li4Yu Huang5Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical UniversitySchool of Pharmaceutical Science, Wenzhou Medical UniversityDepartment of Infectious Diseases, Taizhou First People‘s HospitalDepartment of Infectious Diseases, Zhoushan Hospital Wenzhou Medical UniversityDepartment of Infectious Diseases, Zhoushan Hospital Wenzhou Medical UniversityDepartment of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Chronic hepatitis B (CHB) patients who have sustained virological suppression (SVS) still develop hepatocellular carcinoma(HCC), and the risk factors for developing HCC in these patients are not fully understood. This study included a total of 5234 patients who achieved SVS. After SVS, the incidence rate of HCC was 1.9% in 1–8 years and 1.33% in 9–16 years. There was a significant difference between the two periods (P < 0.001). After 1–8 years and 9–16 years of SVS, after multivariate analysis and IPTW adjustment, the factors related to the occurrence of HCC were men, hypertensive patients, diabetes patients and high FIB-4 scores. In summary, patients with CHB who have achieved SVS may still develop HCC. Among them, men, hypertensive patients, diabetes patients and high FIB-4 scores should be listed as the key monitoring objects of HCC. Clinical trial number: Not applicable.https://doi.org/10.1186/s12885-025-14015-0Chronic hepatitis B(CHB)Sustained virological suppression (SVS)Hepatocellular carcinoma(HCC)Risk factor |
| spellingShingle | Jianna Zhang Zhiqiang Lan Kailu Zhu Sijie Yu Shibo Li Yu Huang Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis B BMC Cancer Chronic hepatitis B(CHB) Sustained virological suppression (SVS) Hepatocellular carcinoma(HCC) Risk factor |
| title | Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis B |
| title_full | Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis B |
| title_fullStr | Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis B |
| title_full_unstemmed | Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis B |
| title_short | Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis B |
| title_sort | analysis of high risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis b |
| topic | Chronic hepatitis B(CHB) Sustained virological suppression (SVS) Hepatocellular carcinoma(HCC) Risk factor |
| url | https://doi.org/10.1186/s12885-025-14015-0 |
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