Agent-based modeling for the tumor microenvironment (TME)
Cancer is a disease that arises from the uncontrolled growth of abnormal (tumor) cells in an organ and their subsequent spread into other parts of the body. If tumor cells spread to surrounding tissues or other organs, then the disease is life-threatening due to limited treatment options. This work...
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| Format: | Article |
| Language: | English |
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AIMS Press
2024-11-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2024335 |
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| author | Hasitha N. Weerasinghe Pamela M. Burrage Dan V. Nicolau Jr. Kevin Burrage |
| author_facet | Hasitha N. Weerasinghe Pamela M. Burrage Dan V. Nicolau Jr. Kevin Burrage |
| author_sort | Hasitha N. Weerasinghe |
| collection | DOAJ |
| description | Cancer is a disease that arises from the uncontrolled growth of abnormal (tumor) cells in an organ and their subsequent spread into other parts of the body. If tumor cells spread to surrounding tissues or other organs, then the disease is life-threatening due to limited treatment options. This work applies an agent-based model to investigate the effect of intra-tumoral communication on tumor progression, plasticity, and invasion, with results suggesting that cell-cell and cell-extracellular matrix (ECM) interactions affect tumor cell behavior. Additionally, the model suggests that low initial healthy cell densities and ECM protein densities promote tumor progression, cell motility, and invasion. Furthermore, high ECM breakdown probabilities of tumor cells promote tumor invasion. Understanding the intra-tumoral communication under cellular stress can potentially lead to the design of successful treatment strategies for cancer. |
| format | Article |
| id | doaj-art-b4a324f7812841c2b8aa77202d72b68a |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-b4a324f7812841c2b8aa77202d72b68a2025-01-23T07:48:07ZengAIMS PressMathematical Biosciences and Engineering1551-00182024-11-0121117621764710.3934/mbe.2024335Agent-based modeling for the tumor microenvironment (TME)Hasitha N. Weerasinghe0Pamela M. Burrage1Dan V. Nicolau Jr.2Kevin Burrage3School of Mathematical Sciences, Queensland University of Technology, Queensland, Brisbane, AustraliaSchool of Mathematical Sciences, Queensland University of Technology, Queensland, Brisbane, AustraliaSchool of Immunology and Microbial Sciences, King’s College London, London, United KingdomSchool of Mathematical Sciences, Queensland University of Technology, Queensland, Brisbane, AustraliaCancer is a disease that arises from the uncontrolled growth of abnormal (tumor) cells in an organ and their subsequent spread into other parts of the body. If tumor cells spread to surrounding tissues or other organs, then the disease is life-threatening due to limited treatment options. This work applies an agent-based model to investigate the effect of intra-tumoral communication on tumor progression, plasticity, and invasion, with results suggesting that cell-cell and cell-extracellular matrix (ECM) interactions affect tumor cell behavior. Additionally, the model suggests that low initial healthy cell densities and ECM protein densities promote tumor progression, cell motility, and invasion. Furthermore, high ECM breakdown probabilities of tumor cells promote tumor invasion. Understanding the intra-tumoral communication under cellular stress can potentially lead to the design of successful treatment strategies for cancer.https://www.aimspress.com/article/doi/10.3934/mbe.2024335tumor microenvironmentcanceragent-based modelingplasticityinvasion |
| spellingShingle | Hasitha N. Weerasinghe Pamela M. Burrage Dan V. Nicolau Jr. Kevin Burrage Agent-based modeling for the tumor microenvironment (TME) Mathematical Biosciences and Engineering tumor microenvironment cancer agent-based modeling plasticity invasion |
| title | Agent-based modeling for the tumor microenvironment (TME) |
| title_full | Agent-based modeling for the tumor microenvironment (TME) |
| title_fullStr | Agent-based modeling for the tumor microenvironment (TME) |
| title_full_unstemmed | Agent-based modeling for the tumor microenvironment (TME) |
| title_short | Agent-based modeling for the tumor microenvironment (TME) |
| title_sort | agent based modeling for the tumor microenvironment tme |
| topic | tumor microenvironment cancer agent-based modeling plasticity invasion |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2024335 |
| work_keys_str_mv | AT hasithanweerasinghe agentbasedmodelingforthetumormicroenvironmenttme AT pamelamburrage agentbasedmodelingforthetumormicroenvironmenttme AT danvnicolaujr agentbasedmodelingforthetumormicroenvironmenttme AT kevinburrage agentbasedmodelingforthetumormicroenvironmenttme |