Predictors of Transplant Regret: A Case–Control Study Nested Within a Prospective Cohort of HSCT Recipients
ABSTRACT Objective To explore pre–hematopoietic stem cell transplant (HSCT) demographic, disease, and psychological factors predictive of future transplant regret and to determine post‐HSCT variables associated with regret. Patients and Methods HSCT candidates participated in a prospective cohort st...
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Wiley
2025-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70828 |
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| author | Janae L. Kirsch James R. Cerhan William J. Hogan Holly C. Edwards Christi A. Patten Tabetha Brockman Christine Hughes Angela Dispenzieri Stephen M. Ansell Dennis A. Gastineau Shawna L. Ehlers |
| author_facet | Janae L. Kirsch James R. Cerhan William J. Hogan Holly C. Edwards Christi A. Patten Tabetha Brockman Christine Hughes Angela Dispenzieri Stephen M. Ansell Dennis A. Gastineau Shawna L. Ehlers |
| author_sort | Janae L. Kirsch |
| collection | DOAJ |
| description | ABSTRACT Objective To explore pre–hematopoietic stem cell transplant (HSCT) demographic, disease, and psychological factors predictive of future transplant regret and to determine post‐HSCT variables associated with regret. Patients and Methods HSCT candidates participated in a prospective cohort study (June 2008–October 2013) examining health behaviors and HSCT outcomes, including completion of standardized surveys at pre‐HSCT (baseline) and 1‐year post‐HSCT. Cases were participants that endorsed regret at 1‐year post‐HSCT follow‐up, and controls were participants without regret at 1 year, matched on age, sex, and transplant type. For cases and controls, pre‐HSCT psychosocial evaluations were abstracted from the electronic health record and coded to determine the Psychosocial Assessment of Candidates for Transplantation score, psychosocial stressors, and mental health diagnoses. The association of selected factors with regret was estimated with odds ratios and 95% confidence intervals from conditional logistic regression models. Results At post‐HSCT, 49 participants of 638 endorsed transplant regret (8%) and formed the case group; 98 controls were matched from remaining participants. Cases and controls were well matched on age (56.6 vs. 57.2 years), sex (both groups 34.7% female), and transplant type (both groups 81.6% autologous). After controlling for the number of hospitalizations and active treatment status, conditional logistic regression revealed that patients who endorsed regret were 3.7 times (95% CI = 1.37–9.69, p = 0.008) more likely to not be in remission compared to controls at 1‐year post‐HSCT. Conclusion Matched case–control analyses revealed that no pre‐HSCT variables collected during the pre‐HSCT evaluation period were predictive of transplant regret, while poorer outcomes at 1‐year after transplant were associated with regret. |
| format | Article |
| id | doaj-art-b4a17d652252402ba7d77d53f7ba3ea3 |
| institution | DOAJ |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-b4a17d652252402ba7d77d53f7ba3ea32025-08-20T02:56:09ZengWileyCancer Medicine2045-76342025-04-01147n/an/a10.1002/cam4.70828Predictors of Transplant Regret: A Case–Control Study Nested Within a Prospective Cohort of HSCT RecipientsJanae L. Kirsch0James R. Cerhan1William J. Hogan2Holly C. Edwards3Christi A. Patten4Tabetha Brockman5Christine Hughes6Angela Dispenzieri7Stephen M. Ansell8Dennis A. Gastineau9Shawna L. Ehlers10Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USADivision of Epidemiology, Department of Health Sciences Research Mayo Clinic Rochester Minnesota USADivision of Hematology, Department of Medicine, College of Medicine Mayo Clinic Rochester Minnesota USADepartment of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USADepartment of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USADepartment of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USADepartment of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USADivision of Hematology, Department of Medicine, College of Medicine Mayo Clinic Rochester Minnesota USADivision of Hematology, Department of Medicine, College of Medicine Mayo Clinic Rochester Minnesota USADivision of Hematology, Department of Medicine, College of Medicine Mayo Clinic Rochester Minnesota USADepartment of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USAABSTRACT Objective To explore pre–hematopoietic stem cell transplant (HSCT) demographic, disease, and psychological factors predictive of future transplant regret and to determine post‐HSCT variables associated with regret. Patients and Methods HSCT candidates participated in a prospective cohort study (June 2008–October 2013) examining health behaviors and HSCT outcomes, including completion of standardized surveys at pre‐HSCT (baseline) and 1‐year post‐HSCT. Cases were participants that endorsed regret at 1‐year post‐HSCT follow‐up, and controls were participants without regret at 1 year, matched on age, sex, and transplant type. For cases and controls, pre‐HSCT psychosocial evaluations were abstracted from the electronic health record and coded to determine the Psychosocial Assessment of Candidates for Transplantation score, psychosocial stressors, and mental health diagnoses. The association of selected factors with regret was estimated with odds ratios and 95% confidence intervals from conditional logistic regression models. Results At post‐HSCT, 49 participants of 638 endorsed transplant regret (8%) and formed the case group; 98 controls were matched from remaining participants. Cases and controls were well matched on age (56.6 vs. 57.2 years), sex (both groups 34.7% female), and transplant type (both groups 81.6% autologous). After controlling for the number of hospitalizations and active treatment status, conditional logistic regression revealed that patients who endorsed regret were 3.7 times (95% CI = 1.37–9.69, p = 0.008) more likely to not be in remission compared to controls at 1‐year post‐HSCT. Conclusion Matched case–control analyses revealed that no pre‐HSCT variables collected during the pre‐HSCT evaluation period were predictive of transplant regret, while poorer outcomes at 1‐year after transplant were associated with regret.https://doi.org/10.1002/cam4.70828health statushematopoietic stem cell transplantillness perceptiononcologytransplant regret |
| spellingShingle | Janae L. Kirsch James R. Cerhan William J. Hogan Holly C. Edwards Christi A. Patten Tabetha Brockman Christine Hughes Angela Dispenzieri Stephen M. Ansell Dennis A. Gastineau Shawna L. Ehlers Predictors of Transplant Regret: A Case–Control Study Nested Within a Prospective Cohort of HSCT Recipients Cancer Medicine health status hematopoietic stem cell transplant illness perception oncology transplant regret |
| title | Predictors of Transplant Regret: A Case–Control Study Nested Within a Prospective Cohort of HSCT Recipients |
| title_full | Predictors of Transplant Regret: A Case–Control Study Nested Within a Prospective Cohort of HSCT Recipients |
| title_fullStr | Predictors of Transplant Regret: A Case–Control Study Nested Within a Prospective Cohort of HSCT Recipients |
| title_full_unstemmed | Predictors of Transplant Regret: A Case–Control Study Nested Within a Prospective Cohort of HSCT Recipients |
| title_short | Predictors of Transplant Regret: A Case–Control Study Nested Within a Prospective Cohort of HSCT Recipients |
| title_sort | predictors of transplant regret a case control study nested within a prospective cohort of hsct recipients |
| topic | health status hematopoietic stem cell transplant illness perception oncology transplant regret |
| url | https://doi.org/10.1002/cam4.70828 |
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