Design and synthesis of pyridazinone hybrid in PEG-400 as COX-1/COX-2 inhibitor and their antioxidant study

Design and synthesis of pyridazinone hybrid in PEG-400 as COX-1/COX-2 inhibitor and their antioxidant study

Abstract The cyclooxygenase 1 and 2 (COX-1 and COX-2) are the key enzymes that are responsible for the conversion of arachidonic acid to prostaglandins. Meanwhile, nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as a double-edged weapon to inhibit COX-1 can lead to gastrointestinal side...

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Main Authors: Omprakash B. Pawar, Anil P. Marale, Deekshaputra R. Birhade, Rahul D. Jawarkar, Avinash G. Ulhe, Gajanan D. Rawate, Nagesh R. Nahate, Shashikant A. Ikhe, Dinesh A. Pund, Gajanan N. Chaudhari, Vivek T. Humne
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Chemistry
Subjects:
Pyridazin-3(2H)-ones
PEG-400
COX-1/COX-2
Antioxidant activity
Online Access:https://doi.org/10.1007/s44371-025-00216-w
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