Design and synthesis of pyridazinone hybrid in PEG-400 as COX-1/COX-2 inhibitor and their antioxidant study
Abstract The cyclooxygenase 1 and 2 (COX-1 and COX-2) are the key enzymes that are responsible for the conversion of arachidonic acid to prostaglandins. Meanwhile, nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as a double-edged weapon to inhibit COX-1 can lead to gastrointestinal side...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-06-01
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| Series: | Discover Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s44371-025-00216-w |
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| Summary: | Abstract The cyclooxygenase 1 and 2 (COX-1 and COX-2) are the key enzymes that are responsible for the conversion of arachidonic acid to prostaglandins. Meanwhile, nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as a double-edged weapon to inhibit COX-1 can lead to gastrointestinal side effects and kidney damage, whereas selective COX-2 inhibition provides anti-inflammatory effects without gastrointestinal toxicity. In this report, we described the modular synthesis of substituted pyridazin-3(2H)-ones in polyethylene glycol-400, as a green solvent. The products were isolated without the use of column chromatography, which makes this process elegant and efficient. The compounds 2e and 2 l show the top-tier selective index for cyclooxygenase, in comparable with celecoxib as a standard. Besides, the antioxidant activity of the synthesized compounds has also been tested. The binding mode of 2 h was evaluated through in silico molecular docking, while ADME assessment studies predicted the drug-like characteristics of the synthesised compounds (2a-p). The newly developed protocol and synthesized compounds may serve as a structural guide for designing and development of cyclooxygenase inhibitors. Graphical abstract |
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| ISSN: | 3005-1193 |