A genome-wide association study of total child psychiatric problems scores.
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric p...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0273116 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850162937965051904 |
|---|---|
| author | Alexander Neumann Ilja M Nolte Irene Pappa Tarunveer S Ahluwalia Erik Pettersson Alina Rodriguez Andrew Whitehouse Catharina E M van Beijsterveldt Beben Benyamin Anke R Hammerschlag Quinta Helmer Ville Karhunen Eva Krapohl Yi Lu Peter J van der Most Teemu Palviainen Beate St Pourcain Ilkka Seppälä Anna Suarez Natalia Vilor-Tejedor Carla M T Tiesler Carol Wang Amanda Wills Ang Zhou Silvia Alemany Hans Bisgaard Klaus Bønnelykke Gareth E Davies Christian Hakulinen Anjali K Henders Elina Hyppönen Jakob Stokholm Meike Bartels Jouke-Jan Hottenga Joachim Heinrich John Hewitt Liisa Keltikangas-Järvinen Tellervo Korhonen Jaakko Kaprio Jari Lahti Marius Lahti-Pulkkinen Terho Lehtimäki Christel M Middeldorp Jackob M Najman Craig Pennell Chris Power Albertine J Oldehinkel Robert Plomin Katri Räikkönen Olli T Raitakari Kaili Rimfeld Lærke Sass Harold Snieder Marie Standl Jordi Sunyer Gail M Williams Marian J Bakermans-Kranenburg Dorret I Boomsma Marinus H van IJzendoorn Catharina A Hartman Henning Tiemeier |
| author_facet | Alexander Neumann Ilja M Nolte Irene Pappa Tarunveer S Ahluwalia Erik Pettersson Alina Rodriguez Andrew Whitehouse Catharina E M van Beijsterveldt Beben Benyamin Anke R Hammerschlag Quinta Helmer Ville Karhunen Eva Krapohl Yi Lu Peter J van der Most Teemu Palviainen Beate St Pourcain Ilkka Seppälä Anna Suarez Natalia Vilor-Tejedor Carla M T Tiesler Carol Wang Amanda Wills Ang Zhou Silvia Alemany Hans Bisgaard Klaus Bønnelykke Gareth E Davies Christian Hakulinen Anjali K Henders Elina Hyppönen Jakob Stokholm Meike Bartels Jouke-Jan Hottenga Joachim Heinrich John Hewitt Liisa Keltikangas-Järvinen Tellervo Korhonen Jaakko Kaprio Jari Lahti Marius Lahti-Pulkkinen Terho Lehtimäki Christel M Middeldorp Jackob M Najman Craig Pennell Chris Power Albertine J Oldehinkel Robert Plomin Katri Räikkönen Olli T Raitakari Kaili Rimfeld Lærke Sass Harold Snieder Marie Standl Jordi Sunyer Gail M Williams Marian J Bakermans-Kranenburg Dorret I Boomsma Marinus H van IJzendoorn Catharina A Hartman Henning Tiemeier |
| author_sort | Alexander Neumann |
| collection | DOAJ |
| description | Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits. |
| format | Article |
| id | doaj-art-b496b6eb00a643ae88ae8e6c418358c3 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b496b6eb00a643ae88ae8e6c418358c32025-08-20T02:22:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01178e027311610.1371/journal.pone.0273116A genome-wide association study of total child psychiatric problems scores.Alexander NeumannIlja M NolteIrene PappaTarunveer S AhluwaliaErik PetterssonAlina RodriguezAndrew WhitehouseCatharina E M van BeijsterveldtBeben BenyaminAnke R HammerschlagQuinta HelmerVille KarhunenEva KrapohlYi LuPeter J van der MostTeemu PalviainenBeate St PourcainIlkka SeppäläAnna SuarezNatalia Vilor-TejedorCarla M T TieslerCarol WangAmanda WillsAng ZhouSilvia AlemanyHans BisgaardKlaus BønnelykkeGareth E DaviesChristian HakulinenAnjali K HendersElina HyppönenJakob StokholmMeike BartelsJouke-Jan HottengaJoachim HeinrichJohn HewittLiisa Keltikangas-JärvinenTellervo KorhonenJaakko KaprioJari LahtiMarius Lahti-PulkkinenTerho LehtimäkiChristel M MiddeldorpJackob M NajmanCraig PennellChris PowerAlbertine J OldehinkelRobert PlominKatri RäikkönenOlli T RaitakariKaili RimfeldLærke SassHarold SniederMarie StandlJordi SunyerGail M WilliamsMarian J Bakermans-KranenburgDorret I BoomsmaMarinus H van IJzendoornCatharina A HartmanHenning TiemeierSubstantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.https://doi.org/10.1371/journal.pone.0273116 |
| spellingShingle | Alexander Neumann Ilja M Nolte Irene Pappa Tarunveer S Ahluwalia Erik Pettersson Alina Rodriguez Andrew Whitehouse Catharina E M van Beijsterveldt Beben Benyamin Anke R Hammerschlag Quinta Helmer Ville Karhunen Eva Krapohl Yi Lu Peter J van der Most Teemu Palviainen Beate St Pourcain Ilkka Seppälä Anna Suarez Natalia Vilor-Tejedor Carla M T Tiesler Carol Wang Amanda Wills Ang Zhou Silvia Alemany Hans Bisgaard Klaus Bønnelykke Gareth E Davies Christian Hakulinen Anjali K Henders Elina Hyppönen Jakob Stokholm Meike Bartels Jouke-Jan Hottenga Joachim Heinrich John Hewitt Liisa Keltikangas-Järvinen Tellervo Korhonen Jaakko Kaprio Jari Lahti Marius Lahti-Pulkkinen Terho Lehtimäki Christel M Middeldorp Jackob M Najman Craig Pennell Chris Power Albertine J Oldehinkel Robert Plomin Katri Räikkönen Olli T Raitakari Kaili Rimfeld Lærke Sass Harold Snieder Marie Standl Jordi Sunyer Gail M Williams Marian J Bakermans-Kranenburg Dorret I Boomsma Marinus H van IJzendoorn Catharina A Hartman Henning Tiemeier A genome-wide association study of total child psychiatric problems scores. PLoS ONE |
| title | A genome-wide association study of total child psychiatric problems scores. |
| title_full | A genome-wide association study of total child psychiatric problems scores. |
| title_fullStr | A genome-wide association study of total child psychiatric problems scores. |
| title_full_unstemmed | A genome-wide association study of total child psychiatric problems scores. |
| title_short | A genome-wide association study of total child psychiatric problems scores. |
| title_sort | genome wide association study of total child psychiatric problems scores |
| url | https://doi.org/10.1371/journal.pone.0273116 |
| work_keys_str_mv | AT alexanderneumann agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT iljamnolte agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT irenepappa agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT tarunveersahluwalia agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT erikpettersson agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT alinarodriguez agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT andrewwhitehouse agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT catharinaemvanbeijsterveldt agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT bebenbenyamin agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT ankerhammerschlag agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT quintahelmer agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT villekarhunen agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT evakrapohl agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT yilu agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT peterjvandermost agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT teemupalviainen agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT beatestpourcain agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT ilkkaseppala agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT annasuarez agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT nataliavilortejedor agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT carlamttiesler agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT carolwang agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT amandawills agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT angzhou agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT silviaalemany agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT hansbisgaard agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT klausbønnelykke agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT garethedavies agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT christianhakulinen agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT anjalikhenders agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT elinahypponen agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jakobstokholm agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT meikebartels agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT joukejanhottenga agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT joachimheinrich agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT johnhewitt agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT liisakeltikangasjarvinen agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT tellervokorhonen agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jaakkokaprio agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jarilahti agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT mariuslahtipulkkinen agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT terholehtimaki agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT christelmmiddeldorp agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jackobmnajman agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT craigpennell agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT chrispower agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT albertinejoldehinkel agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT robertplomin agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT katriraikkonen agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT ollitraitakari agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT kailirimfeld agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT lærkesass agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT haroldsnieder agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT mariestandl agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jordisunyer agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT gailmwilliams agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT marianjbakermanskranenburg agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT dorretiboomsma agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT marinushvanijzendoorn agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT catharinaahartman agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT henningtiemeier agenomewideassociationstudyoftotalchildpsychiatricproblemsscores AT alexanderneumann genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT iljamnolte genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT irenepappa genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT tarunveersahluwalia genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT erikpettersson genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT alinarodriguez genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT andrewwhitehouse genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT catharinaemvanbeijsterveldt genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT bebenbenyamin genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT ankerhammerschlag genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT quintahelmer genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT villekarhunen genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT evakrapohl genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT yilu genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT peterjvandermost genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT teemupalviainen genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT beatestpourcain genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT ilkkaseppala genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT annasuarez genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT nataliavilortejedor genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT carlamttiesler genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT carolwang genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT amandawills genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT angzhou genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT silviaalemany genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT hansbisgaard genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT klausbønnelykke genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT garethedavies genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT christianhakulinen genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT anjalikhenders genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT elinahypponen genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jakobstokholm genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT meikebartels genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT joukejanhottenga genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT joachimheinrich genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT johnhewitt genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT liisakeltikangasjarvinen genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT tellervokorhonen genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jaakkokaprio genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jarilahti genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT mariuslahtipulkkinen genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT terholehtimaki genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT christelmmiddeldorp genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jackobmnajman genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT craigpennell genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT chrispower genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT albertinejoldehinkel genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT robertplomin genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT katriraikkonen genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT ollitraitakari genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT kailirimfeld genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT lærkesass genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT haroldsnieder genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT mariestandl genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT jordisunyer genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT gailmwilliams genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT marianjbakermanskranenburg genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT dorretiboomsma genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT marinushvanijzendoorn genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT catharinaahartman genomewideassociationstudyoftotalchildpsychiatricproblemsscores AT henningtiemeier genomewideassociationstudyoftotalchildpsychiatricproblemsscores |