Perineural dexamethasone: neurotoxicity or neuroprotection? A systematic review of preclinical evidence

Perineural dexamethasone: neurotoxicity or neuroprotection? A systematic review of preclinical evidence

Abstract Background Perineural dexamethasone is widely used as an adjuvant to local anesthetics in regional anesthesia to prolong analgesia. However, concerns persist regarding its potential neurotoxic effects, particularly when administered perineurally. This systematic review aims to synthesize pr...

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Main Authors: Alessandro De Cassai, Domenico Pietro Santonastaso, Francesco Coppolino, Cristiano D’Errico, Gabriele Melegari, Burhan Dost, Giulia Aviani Fulvio, Annalisa Boscolo, Rafael Boscolo-Berto, Paolo Navalesi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Anesthesia, Analgesia and Critical Care
Subjects:
Dexamethasone
Neuroprotective
Neurotoxic
Perineural
Safety
Online Access:https://doi.org/10.1186/s44158-025-00271-w
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