Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy

Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy

Abstract Diabetic retinopathy (DR) is the major cause of vision decline in adults worldwide. Photoreceptor loss is considered a main pathogenesis of retinal dysfunction in DR. Recently, mesenchymal stem cell-derived extracellular vesicles (MEVs) treatment has been considered a promising cell-free ap...

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Bibliographic Details
Main Authors: Yaoxiang Sun, Shenyuan Chen, Xiaoyuan Qi, Yuntong Sun, Zhengmei Jiang, Jie Chang, Yongjun Ma, Jin Huang, Benshuai You, Fengtian Sun
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Nanobiotechnology
Subjects:
Photoreceptor
Extracellular vesicles
Diabetic retinopathy
CRYAA
USP25
Online Access:https://doi.org/10.1186/s12951-025-03671-w
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