The Effects of Neuronal <i>Fyn</i> Knockdown in the Hippocampus in the Rat Kainate Model of Temporal Lobe Epilepsy

The Effects of Neuronal <i>Fyn</i> Knockdown in the Hippocampus in the Rat Kainate Model of Temporal Lobe Epilepsy

Previous studies have demonstrated neuronal and microglial Fyn, a Src family kinase (SFK), and how its interactions with tau contribute to epileptogenesis. Saracatinib, a Fyn/SFK inhibitor, modifies disease progression in rat kainate (KA) epilepsy models. In this study, we investigated neuronal-spec...

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Bibliographic Details
Main Authors: Nikhil S. Rao, Marson Putra, Christina Meyer, Sirisha Parameswaran, Thimmasettappa Thippeswamy
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
<i>fyn</i> knockdown
Src family kinase
epilepsy
neurodegeneration
neuroinflammation
Online Access:https://www.mdpi.com/2073-4409/14/10/743
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