A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This Time
Invasive aspergillosis (IA) is a life-threatening infection that mainly affects immunocompromised hosts. Cardiac involvement is rare but can be the sole presentation of IA. It is associated with a high mortality rate and mostly occurs in patients with pre-existing cardiac disease. It can also be see...
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MDPI AG
2025-06-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/11/7/486 |
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| author | Zaid Al Khouri Hunter Smeltzer Anood Al Qura’an Mohammad H. Khan Alexandre E. Malek |
| author_facet | Zaid Al Khouri Hunter Smeltzer Anood Al Qura’an Mohammad H. Khan Alexandre E. Malek |
| author_sort | Zaid Al Khouri |
| collection | DOAJ |
| description | Invasive aspergillosis (IA) is a life-threatening infection that mainly affects immunocompromised hosts. Cardiac involvement is rare but can be the sole presentation of IA. It is associated with a high mortality rate and mostly occurs in patients with pre-existing cardiac disease. It can also be seen in immunocompetent patients with a structurally normal heart. The reported cases of cardiac involvement are usually due to infectious endocarditis (IE) caused by <i>Aspergillus</i> species (most commonly <i>Aspergillus fumigatus</i>). However, there is limited data on non-valvular cardiac aspergillosis (NVCA). We reviewed 67 cases of NVCA published between 1950–2024 and reported an additional case from our institution involving a 48-year-old female with kyphoscoliosis diagnosed with <i>Aspergillus</i> pericarditis. |
| format | Article |
| id | doaj-art-b48aad1b405e4a7a93a3e7fd0379690d |
| institution | Kabale University |
| issn | 2309-608X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj-art-b48aad1b405e4a7a93a3e7fd0379690d2025-08-20T03:36:11ZengMDPI AGJournal of Fungi2309-608X2025-06-0111748610.3390/jof11070486A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This TimeZaid Al Khouri0Hunter Smeltzer1Anood Al Qura’an2Mohammad H. Khan3Alexandre E. Malek4Department of Medicine, Division of Infectious Diseases, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USADepartment of Medicine, Division of Infectious Diseases, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USADepartment of Medicine, Division of Infectious Diseases, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USADepartment of Medicine, Division of Infectious Diseases, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USADepartment of Medicine, Division of Infectious Diseases, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USAInvasive aspergillosis (IA) is a life-threatening infection that mainly affects immunocompromised hosts. Cardiac involvement is rare but can be the sole presentation of IA. It is associated with a high mortality rate and mostly occurs in patients with pre-existing cardiac disease. It can also be seen in immunocompetent patients with a structurally normal heart. The reported cases of cardiac involvement are usually due to infectious endocarditis (IE) caused by <i>Aspergillus</i> species (most commonly <i>Aspergillus fumigatus</i>). However, there is limited data on non-valvular cardiac aspergillosis (NVCA). We reviewed 67 cases of NVCA published between 1950–2024 and reported an additional case from our institution involving a 48-year-old female with kyphoscoliosis diagnosed with <i>Aspergillus</i> pericarditis.https://www.mdpi.com/2309-608X/11/7/486<i>Aspergillus</i>cardiacpericardiummyocardiuminvasive fungal infection |
| spellingShingle | Zaid Al Khouri Hunter Smeltzer Anood Al Qura’an Mohammad H. Khan Alexandre E. Malek A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This Time Journal of Fungi <i>Aspergillus</i> cardiac pericardium myocardium invasive fungal infection |
| title | A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This Time |
| title_full | A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This Time |
| title_fullStr | A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This Time |
| title_full_unstemmed | A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This Time |
| title_short | A Distinct Clinical Entity of Invasive Cardiac Aspergillosis: Not the Heart Valves This Time |
| title_sort | distinct clinical entity of invasive cardiac aspergillosis not the heart valves this time |
| topic | <i>Aspergillus</i> cardiac pericardium myocardium invasive fungal infection |
| url | https://www.mdpi.com/2309-608X/11/7/486 |
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