Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysis
Aim: The study aimed to explore the incidence of cancer as an adverse event to SGLT2 inhibitors (SGLT2i) use in Type 2 diabetes.Materials & methods: The study followed PRISMA guidelines to pool RCTs conforming the inclusion criteria. Random effects model was used to pool risk ratios.Results &...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Future Science OA |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2024.2400797 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850099648594706432 |
|---|---|
| author | Muhammad Ishtiaq Obaid Mohammad Saiem Shahzad Fakhar Latif Muhammad Hamza Khan Moeez Akram Syed Asad Mehdi Rizvi Rana Muhammad Umer Nasrullah Dayab Asad Muhammad Adil Obaid |
| author_facet | Muhammad Ishtiaq Obaid Mohammad Saiem Shahzad Fakhar Latif Muhammad Hamza Khan Moeez Akram Syed Asad Mehdi Rizvi Rana Muhammad Umer Nasrullah Dayab Asad Muhammad Adil Obaid |
| author_sort | Muhammad Ishtiaq Obaid |
| collection | DOAJ |
| description | Aim: The study aimed to explore the incidence of cancer as an adverse event to SGLT2 inhibitors (SGLT2i) use in Type 2 diabetes.Materials & methods: The study followed PRISMA guidelines to pool RCTs conforming the inclusion criteria. Random effects model was used to pool risk ratios.Results & conclusion: After reviewing 19 studies, the analysis suggested a possible increased risk of reproductive, breast, thyroid, hematologic/lymphatic, urinary, skin and skeletal cancers with SGLT2i use. Conversely, lower incidences of respiratory and cardiovascular cancers were noted. However, these associations lacked statistical significance. Caution is advised in using SGLT2i due to potential cancer risks, especially in diabetic patients prone to cancer. More RCTs are essential due to limited research in this area. |
| format | Article |
| id | doaj-art-b48932bbb4824e998f9c9a9eb2a4ab67 |
| institution | DOAJ |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-b48932bbb4824e998f9c9a9eb2a4ab672025-08-20T02:40:27ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.1080/20565623.2024.2400797Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysisMuhammad Ishtiaq Obaid0Mohammad Saiem Shahzad1Fakhar Latif2Muhammad Hamza Khan3Moeez Akram4Syed Asad Mehdi Rizvi5Rana Muhammad Umer Nasrullah6Dayab Asad7Muhammad Adil Obaid8Department of Medicine, Bahria University Medical & Dental College, Karachi, 74400, PakistanDepartment of Medicine, Bahria University Medical & Dental College, Karachi, 74400, PakistanDepartment of Medicine, Dow Medical College, Karachi, 74700, PakistanDepartment of Medicine, Karachi Medical & Dental College, Karachi, 74700, PakistanDepartment of Medicine, Allama Iqbal Medical College, Lahore, 54700, PakistanDepartment of Medicine, Jinnah Sindh Medical University, Karachi, 75510, PakistanDepartment of Medicine, Jinnah Sindh Medical University, Karachi, 75510, PakistanDepartment of Medicine, Jinnah Sindh Medical University, Karachi, 75510, PakistanDepartment of Medicine, Jinnah Sindh Medical University, Karachi, 75510, PakistanAim: The study aimed to explore the incidence of cancer as an adverse event to SGLT2 inhibitors (SGLT2i) use in Type 2 diabetes.Materials & methods: The study followed PRISMA guidelines to pool RCTs conforming the inclusion criteria. Random effects model was used to pool risk ratios.Results & conclusion: After reviewing 19 studies, the analysis suggested a possible increased risk of reproductive, breast, thyroid, hematologic/lymphatic, urinary, skin and skeletal cancers with SGLT2i use. Conversely, lower incidences of respiratory and cardiovascular cancers were noted. However, these associations lacked statistical significance. Caution is advised in using SGLT2i due to potential cancer risks, especially in diabetic patients prone to cancer. More RCTs are essential due to limited research in this area.https://www.tandfonline.com/doi/10.1080/20565623.2024.2400797antidiabetic medicationcancer incidencecancer riskdiabetes mellitusmalignancymeta-analysis |
| spellingShingle | Muhammad Ishtiaq Obaid Mohammad Saiem Shahzad Fakhar Latif Muhammad Hamza Khan Moeez Akram Syed Asad Mehdi Rizvi Rana Muhammad Umer Nasrullah Dayab Asad Muhammad Adil Obaid Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysis Future Science OA antidiabetic medication cancer incidence cancer risk diabetes mellitus malignancy meta-analysis |
| title | Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysis |
| title_full | Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysis |
| title_fullStr | Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysis |
| title_full_unstemmed | Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysis |
| title_short | Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysis |
| title_sort | relationship between sglt2 inhibitor use and specific cancer types a systematic review and meta analysis |
| topic | antidiabetic medication cancer incidence cancer risk diabetes mellitus malignancy meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2024.2400797 |
| work_keys_str_mv | AT muhammadishtiaqobaid relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis AT mohammadsaiemshahzad relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis AT fakharlatif relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis AT muhammadhamzakhan relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis AT moeezakram relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis AT syedasadmehdirizvi relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis AT ranamuhammadumernasrullah relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis AT dayabasad relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis AT muhammadadilobaid relationshipbetweensglt2inhibitoruseandspecificcancertypesasystematicreviewandmetaanalysis |