Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults
ObjectiveThis study evaluated the performance of the SiJoy GS1 Continuous Glucose Monitor (CGM) system by analyzing the time lag between plasma glucose (PG) and CGM measurements during an Oral Glucose Tolerance Test (OGTT) in healthy adults. This investigation would elucidate the implications of phy...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1536292/full |
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| author | Wanyi Zhao Wanyi Zhao Wanyi Zhao Wanyi Zhao Wanyi Zhao Dongmei Zheng Dongmei Zheng Dongmei Zheng Dongmei Zheng Dongmei Zheng Xianbao Shi Feng Xu Feng Xu Lin Chen Lin Chen Xingmei Liu Xingmei Liu Xingmei Liu Xingmei Liu Xiaolong Jin Xiaolong Jin Qingbo Guan Qingbo Guan Qingbo Guan Qingbo Guan Qingbo Guan Chao Xu Chao Xu Chao Xu Chao Xu Chao Xu |
| author_facet | Wanyi Zhao Wanyi Zhao Wanyi Zhao Wanyi Zhao Wanyi Zhao Dongmei Zheng Dongmei Zheng Dongmei Zheng Dongmei Zheng Dongmei Zheng Xianbao Shi Feng Xu Feng Xu Lin Chen Lin Chen Xingmei Liu Xingmei Liu Xingmei Liu Xingmei Liu Xiaolong Jin Xiaolong Jin Qingbo Guan Qingbo Guan Qingbo Guan Qingbo Guan Qingbo Guan Chao Xu Chao Xu Chao Xu Chao Xu Chao Xu |
| author_sort | Wanyi Zhao |
| collection | DOAJ |
| description | ObjectiveThis study evaluated the performance of the SiJoy GS1 Continuous Glucose Monitor (CGM) system by analyzing the time lag between plasma glucose (PG) and CGM measurements during an Oral Glucose Tolerance Test (OGTT) in healthy adults. This investigation would elucidate the implications of physiological delay time and optimize technical delays in populations.Research design and methodsA total of 129 participants wore SiJoy GS1 sensors on their posterior upper arms for at least 48 hours before undergoing an OGTT.ResultsTo minimize the Mean Absolute Relative Difference (MARD), two approaches were tested: MARD minimization and minimum deviation match. The demographic characteristics of the participants included a mean age of 37.62 (± 11.21) years, height of 169.84 (± 7.81) cm, and weight of 71.86 (± 18.0) kg. Among them 69.0% were healthy. SiJoy GS1 sensors exhibit an excellent performance of consistency with 96.6% at 20/20% and MARD of 8.01(± 4.9) % at the fasting phase. The consensus error grid results showed 89.22% of all values fell within Zone A, and 100% of values were in Zone A+B collectively. In terms of minimizing Mean Absolute Relative Difference (MARD), at 30 minutes of OGTT, the first method suggested a 15-minute delay while the second proposed a 10-minute average delay time. The latter approach was more suitable due to the less variability in the timing of glucose peaks during the OGTT.ConclusionsIn the study, the SiJoy GS1 sensor exhibited consistent performance. Its accuracy was unaffected by subject characteristics. The application of the minimum deviation match method proved advantageous in reducing the CGM delay time. |
| format | Article |
| id | doaj-art-b484a7a714f0448ea87dcadd8dee520d |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-b484a7a714f0448ea87dcadd8dee520d2025-08-20T03:24:07ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15362921536292Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adultsWanyi Zhao0Wanyi Zhao1Wanyi Zhao2Wanyi Zhao3Wanyi Zhao4Dongmei Zheng5Dongmei Zheng6Dongmei Zheng7Dongmei Zheng8Dongmei Zheng9Xianbao Shi10Feng Xu11Feng Xu12Lin Chen13Lin Chen14Xingmei Liu15Xingmei Liu16Xingmei Liu17Xingmei Liu18Xiaolong Jin19Xiaolong Jin20Qingbo Guan21Qingbo Guan22Qingbo Guan23Qingbo Guan24Qingbo Guan25Chao Xu26Chao Xu27Chao Xu28Chao Xu29Chao Xu30Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaKeyLaboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaKeyLaboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShenzhen Sibionics Co.Ltd, Shenzhen, ChinaKeyLaboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaKeyLaboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaKeyLaboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaKeyLaboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaKeyLaboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, ChinaKeyLaboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaObjectiveThis study evaluated the performance of the SiJoy GS1 Continuous Glucose Monitor (CGM) system by analyzing the time lag between plasma glucose (PG) and CGM measurements during an Oral Glucose Tolerance Test (OGTT) in healthy adults. This investigation would elucidate the implications of physiological delay time and optimize technical delays in populations.Research design and methodsA total of 129 participants wore SiJoy GS1 sensors on their posterior upper arms for at least 48 hours before undergoing an OGTT.ResultsTo minimize the Mean Absolute Relative Difference (MARD), two approaches were tested: MARD minimization and minimum deviation match. The demographic characteristics of the participants included a mean age of 37.62 (± 11.21) years, height of 169.84 (± 7.81) cm, and weight of 71.86 (± 18.0) kg. Among them 69.0% were healthy. SiJoy GS1 sensors exhibit an excellent performance of consistency with 96.6% at 20/20% and MARD of 8.01(± 4.9) % at the fasting phase. The consensus error grid results showed 89.22% of all values fell within Zone A, and 100% of values were in Zone A+B collectively. In terms of minimizing Mean Absolute Relative Difference (MARD), at 30 minutes of OGTT, the first method suggested a 15-minute delay while the second proposed a 10-minute average delay time. The latter approach was more suitable due to the less variability in the timing of glucose peaks during the OGTT.ConclusionsIn the study, the SiJoy GS1 sensor exhibited consistent performance. Its accuracy was unaffected by subject characteristics. The application of the minimum deviation match method proved advantageous in reducing the CGM delay time.https://www.frontiersin.org/articles/10.3389/fendo.2025.1536292/fullcontinuous glucose monitoring (CGM)plasma glucoseaccuracyglucose controlanalytical bias |
| spellingShingle | Wanyi Zhao Wanyi Zhao Wanyi Zhao Wanyi Zhao Wanyi Zhao Dongmei Zheng Dongmei Zheng Dongmei Zheng Dongmei Zheng Dongmei Zheng Xianbao Shi Feng Xu Feng Xu Lin Chen Lin Chen Xingmei Liu Xingmei Liu Xingmei Liu Xingmei Liu Xiaolong Jin Xiaolong Jin Qingbo Guan Qingbo Guan Qingbo Guan Qingbo Guan Qingbo Guan Chao Xu Chao Xu Chao Xu Chao Xu Chao Xu Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults Frontiers in Endocrinology continuous glucose monitoring (CGM) plasma glucose accuracy glucose control analytical bias |
| title | Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults |
| title_full | Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults |
| title_fullStr | Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults |
| title_full_unstemmed | Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults |
| title_short | Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults |
| title_sort | clinical performance evaluation of the sijoy gs1 continuous glucose monitor during oral glucose tolerance testing in healthy adults |
| topic | continuous glucose monitoring (CGM) plasma glucose accuracy glucose control analytical bias |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1536292/full |
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