A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits.
<h4>Background</h4>DNA methylation (DNAm) provides a window to characterize the impacts of environmental exposures and the biological aging process. Epigenetic clocks are often trained on DNAm using penalized regression of CpG sites, but recent evidence suggests potential benefits of tra...
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Main Authors: | Dennis Khodasevich, Nina Holland, Lars van der Laan, Andres Cardenas |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2025-02-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1012768 |
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