Shallot-Peel Extract Supplementation Increases Glutathione Levels in Gastritis Rat Model
Background: Mefenamic acid can cause gastritis. Glutathione is one of the oxidative stress defense mechanisms and nutrient supplementation containing high antioxidants. Peel of shallot (Allium cepa var. Ascalonicum) contains higher antioxidant compounds and may increase glutathione levels. This stud...
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Universitas Padjadjaran
2024-09-01
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| Series: | Althea Medical Journal |
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| Online Access: | https://journal.fk.unpad.ac.id/index.php/amj/article/view/3250 |
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| author | Zahrah Febianti Bagas Wahyu Utama Adelia Handoko |
| author_facet | Zahrah Febianti Bagas Wahyu Utama Adelia Handoko |
| author_sort | Zahrah Febianti |
| collection | DOAJ |
| description | Background: Mefenamic acid can cause gastritis. Glutathione is one of the oxidative stress defense mechanisms and nutrient supplementation containing high antioxidants. Peel of shallot (Allium cepa var. Ascalonicum) contains higher antioxidant compounds and may increase glutathione levels. This study aimed to analyze the effect of shallot peel extract supplementation on gastric glutathione (GSH) levels in gastritis rats model.
Methods: This was an experimental study using 24 male Wistar rats which were divided into 4 groups, namely group K0 (given 2 ml of aquadest for 14 days); group K1 (given mefenamic acid 23.25 mg/day for the first 7 days, then Na-CMC 2 ml/day for the next 7 days), group P1 and P2 (given mefenamic acid 23.25 mg/day for the first 7 days, then given shallot peel extract for the next 7 days at dose of 600 mg/kgBW/day or 1200 mg/kgBW/day). Gastric GSH levels were determined by the Ellman method. The data was analyzed by ANOVA and post hoc test.
Results: The shallot peel extract supplementation at a dose of 600 mg/kgBW and 1200 mg/kgBW significantly increased gastric GSH levels in gastritis rats (p<0.05), however, GSH levels did not reach normal conditions. Linear regression analysis showed an R coefficient of 0.751.
Conclusion: Shallot peel extract supplementation increases gastric GSH levels in gastritis rats model in a dose-dependent manner, suggesting an effective dose of shallot peel extract. Further study to develop shallot peel extract into phytopharmaca is imperative. |
| format | Article |
| id | doaj-art-b481e66bdf444f94b2cdbd31d92a59d3 |
| institution | OA Journals |
| issn | 2337-4330 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Universitas Padjadjaran |
| record_format | Article |
| series | Althea Medical Journal |
| spelling | doaj-art-b481e66bdf444f94b2cdbd31d92a59d32025-08-20T02:39:04ZengUniversitas PadjadjaranAlthea Medical Journal2337-43302024-09-0111317217610.15850/amj.v11n3.32501778Shallot-Peel Extract Supplementation Increases Glutathione Levels in Gastritis Rat ModelZahrah Febianti0Bagas Wahyu Utama1Adelia Handoko2Department of Biochemistry, Faculty of Medicine, University of JemberMedical Program, Faculty of Medicine, University of JemberDepartment of Physiology, Faculty of Medicine, University of JemberBackground: Mefenamic acid can cause gastritis. Glutathione is one of the oxidative stress defense mechanisms and nutrient supplementation containing high antioxidants. Peel of shallot (Allium cepa var. Ascalonicum) contains higher antioxidant compounds and may increase glutathione levels. This study aimed to analyze the effect of shallot peel extract supplementation on gastric glutathione (GSH) levels in gastritis rats model. Methods: This was an experimental study using 24 male Wistar rats which were divided into 4 groups, namely group K0 (given 2 ml of aquadest for 14 days); group K1 (given mefenamic acid 23.25 mg/day for the first 7 days, then Na-CMC 2 ml/day for the next 7 days), group P1 and P2 (given mefenamic acid 23.25 mg/day for the first 7 days, then given shallot peel extract for the next 7 days at dose of 600 mg/kgBW/day or 1200 mg/kgBW/day). Gastric GSH levels were determined by the Ellman method. The data was analyzed by ANOVA and post hoc test. Results: The shallot peel extract supplementation at a dose of 600 mg/kgBW and 1200 mg/kgBW significantly increased gastric GSH levels in gastritis rats (p<0.05), however, GSH levels did not reach normal conditions. Linear regression analysis showed an R coefficient of 0.751. Conclusion: Shallot peel extract supplementation increases gastric GSH levels in gastritis rats model in a dose-dependent manner, suggesting an effective dose of shallot peel extract. Further study to develop shallot peel extract into phytopharmaca is imperative.https://journal.fk.unpad.ac.id/index.php/amj/article/view/3250gastric glutathione (gsh), mefenamic acid, stress oxidative |
| spellingShingle | Zahrah Febianti Bagas Wahyu Utama Adelia Handoko Shallot-Peel Extract Supplementation Increases Glutathione Levels in Gastritis Rat Model Althea Medical Journal gastric glutathione (gsh), mefenamic acid, stress oxidative |
| title | Shallot-Peel Extract Supplementation Increases Glutathione Levels in Gastritis Rat Model |
| title_full | Shallot-Peel Extract Supplementation Increases Glutathione Levels in Gastritis Rat Model |
| title_fullStr | Shallot-Peel Extract Supplementation Increases Glutathione Levels in Gastritis Rat Model |
| title_full_unstemmed | Shallot-Peel Extract Supplementation Increases Glutathione Levels in Gastritis Rat Model |
| title_short | Shallot-Peel Extract Supplementation Increases Glutathione Levels in Gastritis Rat Model |
| title_sort | shallot peel extract supplementation increases glutathione levels in gastritis rat model |
| topic | gastric glutathione (gsh), mefenamic acid, stress oxidative |
| url | https://journal.fk.unpad.ac.id/index.php/amj/article/view/3250 |
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