Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering
We described a sacrificial molding for the formation of microfluidic networks. In this molding, the micromolded calcium alginate (Ca-Alg) is introduced as a sacrificial template. The basis of this procedure is fabricating a micromolded Ca-Alg hydrogel and encapsulating this model within a second gel...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/3148652 |
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| _version_ | 1849396342041870336 |
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| author | Meng Wang Xiaoning Yang Lanju Liang |
| author_facet | Meng Wang Xiaoning Yang Lanju Liang |
| author_sort | Meng Wang |
| collection | DOAJ |
| description | We described a sacrificial molding for the formation of microfluidic networks. In this molding, the micromolded calcium alginate (Ca-Alg) is introduced as a sacrificial template. The basis of this procedure is fabricating a micromolded Ca-Alg hydrogel and encapsulating this model within a second gel and removing it by ion-exchange to leave a microchannel in the remaining gel. This microfluidic system can readily deliver solutes into the channels and even control the transport of solutes from channels into the bulk of the gels. Furthermore, the perfused vascular channels can sustain the metabolic activity of encapsulated cells, indicating the feasibility of this microfluidic system in the field of tissue engineering. |
| format | Article |
| id | doaj-art-b47ceca243b14e54bb6cf495c5d0493b |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-b47ceca243b14e54bb6cf495c5d0493b2025-08-20T03:39:22ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/31486523148652Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues EngineeringMeng Wang0Xiaoning Yang1Lanju Liang2School of Opto-Electronic Engineering, Zaozhuang University, Zaozhuang 277160, ChinaResearch Institute of Surface Engineering, Taiyuan University of Technology, Taiyuan 030024, ChinaSchool of Opto-Electronic Engineering, Zaozhuang University, Zaozhuang 277160, ChinaWe described a sacrificial molding for the formation of microfluidic networks. In this molding, the micromolded calcium alginate (Ca-Alg) is introduced as a sacrificial template. The basis of this procedure is fabricating a micromolded Ca-Alg hydrogel and encapsulating this model within a second gel and removing it by ion-exchange to leave a microchannel in the remaining gel. This microfluidic system can readily deliver solutes into the channels and even control the transport of solutes from channels into the bulk of the gels. Furthermore, the perfused vascular channels can sustain the metabolic activity of encapsulated cells, indicating the feasibility of this microfluidic system in the field of tissue engineering.http://dx.doi.org/10.1155/2020/3148652 |
| spellingShingle | Meng Wang Xiaoning Yang Lanju Liang Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering Journal of Chemistry |
| title | Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering |
| title_full | Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering |
| title_fullStr | Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering |
| title_full_unstemmed | Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering |
| title_short | Fabrication of a Microfluidic System Using Micromolded Alginate Gel as a Sacrificial Material for Tissues Engineering |
| title_sort | fabrication of a microfluidic system using micromolded alginate gel as a sacrificial material for tissues engineering |
| url | http://dx.doi.org/10.1155/2020/3148652 |
| work_keys_str_mv | AT mengwang fabricationofamicrofluidicsystemusingmicromoldedalginategelasasacrificialmaterialfortissuesengineering AT xiaoningyang fabricationofamicrofluidicsystemusingmicromoldedalginategelasasacrificialmaterialfortissuesengineering AT lanjuliang fabricationofamicrofluidicsystemusingmicromoldedalginategelasasacrificialmaterialfortissuesengineering |