Human blood metabolites and gastric cancer: a Mendelian randomization analysis
Abstract Background Gastric cancer (GC) remains one of the predominant malignant tumors within the digestive tract, yet its underlying biological mechanisms remain elusive. The primary objective of this study is to delineate the causal relationship between circulating metabolites and GC. Method The...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-024-03576-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559386969866240 |
|---|---|
| author | Chao Zhang Dao Lai Huang Kun Zhou Jin Tao Cai Dang Liu Ming Hao Tan Guan Yu Zhu Xiang Hua Wu |
| author_facet | Chao Zhang Dao Lai Huang Kun Zhou Jin Tao Cai Dang Liu Ming Hao Tan Guan Yu Zhu Xiang Hua Wu |
| author_sort | Chao Zhang |
| collection | DOAJ |
| description | Abstract Background Gastric cancer (GC) remains one of the predominant malignant tumors within the digestive tract, yet its underlying biological mechanisms remain elusive. The primary objective of this study is to delineate the causal relationship between circulating metabolites and GC. Method The primary Mendelian randomization (MR) analysis was based on three large GWAS datasets. While the inverse variance weighted served as the primary analysis technique for investigating causal relationships, additional sensitivity analyses were facilitated through methods such as MR-PRESSO, the weighted median, and MR-Egger. Subsequently, replication, meta-analysis, and multivariable MR were executed using another GC GWAS. Results The results of this study indicated significant associations between three metabolites 3-methyl-2-oxovalerate (OR 5.8, 95%CI: 1.53–22.05, p = 0.0099), piperine (OR 2.05, 95%CI: 1.13–3.7, p = 0.0175), Phe-Phe dipeptide (OR 0.16, 95%CI: 0.03–0.93, p = 0.0409) and GC. Conclusion The present study provides evidence supporting a causal relationship between these three circulating metabolites and GC risk. Elevated levels of 3-methyl-2-oxovalerate and piperine may increase the risk of GC, while Phe-Phe dipeptide may have a protective effect. By integrating genomics and metabolomics, we offer a novel perspective on the biological mechanisms underlying GC. Such insights have the potential to enhance strategies for the screening, prevention, and treatment of GC. |
| format | Article |
| id | doaj-art-b47c7c9ce9644aac89284a800653638b |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-b47c7c9ce9644aac89284a800653638b2025-01-05T12:32:06ZengBMCBMC Gastroenterology1471-230X2024-12-0124111410.1186/s12876-024-03576-2Human blood metabolites and gastric cancer: a Mendelian randomization analysisChao Zhang0Dao Lai Huang1Kun Zhou2Jin Tao Cai3Dang Liu4Ming Hao Tan5Guan Yu Zhu6Xiang Hua Wu7Guangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityGuangxi Medical UniversityAbstract Background Gastric cancer (GC) remains one of the predominant malignant tumors within the digestive tract, yet its underlying biological mechanisms remain elusive. The primary objective of this study is to delineate the causal relationship between circulating metabolites and GC. Method The primary Mendelian randomization (MR) analysis was based on three large GWAS datasets. While the inverse variance weighted served as the primary analysis technique for investigating causal relationships, additional sensitivity analyses were facilitated through methods such as MR-PRESSO, the weighted median, and MR-Egger. Subsequently, replication, meta-analysis, and multivariable MR were executed using another GC GWAS. Results The results of this study indicated significant associations between three metabolites 3-methyl-2-oxovalerate (OR 5.8, 95%CI: 1.53–22.05, p = 0.0099), piperine (OR 2.05, 95%CI: 1.13–3.7, p = 0.0175), Phe-Phe dipeptide (OR 0.16, 95%CI: 0.03–0.93, p = 0.0409) and GC. Conclusion The present study provides evidence supporting a causal relationship between these three circulating metabolites and GC risk. Elevated levels of 3-methyl-2-oxovalerate and piperine may increase the risk of GC, while Phe-Phe dipeptide may have a protective effect. By integrating genomics and metabolomics, we offer a novel perspective on the biological mechanisms underlying GC. Such insights have the potential to enhance strategies for the screening, prevention, and treatment of GC.https://doi.org/10.1186/s12876-024-03576-2Blood metabolitesCausalityGastric cancerMendelian randomization |
| spellingShingle | Chao Zhang Dao Lai Huang Kun Zhou Jin Tao Cai Dang Liu Ming Hao Tan Guan Yu Zhu Xiang Hua Wu Human blood metabolites and gastric cancer: a Mendelian randomization analysis BMC Gastroenterology Blood metabolites Causality Gastric cancer Mendelian randomization |
| title | Human blood metabolites and gastric cancer: a Mendelian randomization analysis |
| title_full | Human blood metabolites and gastric cancer: a Mendelian randomization analysis |
| title_fullStr | Human blood metabolites and gastric cancer: a Mendelian randomization analysis |
| title_full_unstemmed | Human blood metabolites and gastric cancer: a Mendelian randomization analysis |
| title_short | Human blood metabolites and gastric cancer: a Mendelian randomization analysis |
| title_sort | human blood metabolites and gastric cancer a mendelian randomization analysis |
| topic | Blood metabolites Causality Gastric cancer Mendelian randomization |
| url | https://doi.org/10.1186/s12876-024-03576-2 |
| work_keys_str_mv | AT chaozhang humanbloodmetabolitesandgastriccanceramendelianrandomizationanalysis AT daolaihuang humanbloodmetabolitesandgastriccanceramendelianrandomizationanalysis AT kunzhou humanbloodmetabolitesandgastriccanceramendelianrandomizationanalysis AT jintaocai humanbloodmetabolitesandgastriccanceramendelianrandomizationanalysis AT dangliu humanbloodmetabolitesandgastriccanceramendelianrandomizationanalysis AT minghaotan humanbloodmetabolitesandgastriccanceramendelianrandomizationanalysis AT guanyuzhu humanbloodmetabolitesandgastriccanceramendelianrandomizationanalysis AT xianghuawu humanbloodmetabolitesandgastriccanceramendelianrandomizationanalysis |