Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortality
Aim:We aimed to determine the efficacy of presepsin (PRE) as a biomarker of sepsis and to asssess its prognostic value for prediction of mortality were determined.Methods:Selected clinical data of 21 patients admitted to intensive care unit for systemic inflammatory response syndrome (SIRS), sepsis...
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Galenos Publishing House
2020-03-01
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| Series: | Haseki Tıp Bülteni |
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| author | İbrahim Akkoç Zümrüt Mine Işık Sağlam Öznur Şen Nurdan Aydın Macit Koldaş Mehmet Toptaş Sinan Uzman |
| author_facet | İbrahim Akkoç Zümrüt Mine Işık Sağlam Öznur Şen Nurdan Aydın Macit Koldaş Mehmet Toptaş Sinan Uzman |
| author_sort | İbrahim Akkoç |
| collection | DOAJ |
| description | Aim:We aimed to determine the efficacy of presepsin (PRE) as a biomarker of sepsis and to asssess its prognostic value for prediction of mortality were determined.Methods:Selected clinical data of 21 patients admitted to intensive care unit for systemic inflammatory response syndrome (SIRS), sepsis and septic shock were collected. APACHE-II score, blood culture results and WBC and CRP measured at baseline, procalcitonin (PCT) and PRE measured at baseline and on days 2, 4, and 7, and mortality of patients were recorded.Results:Compared to SIRS, sepsis and septic shock caused comparable increases in the APACHE II scores and mortality rates. The PRE values of the septic shock patients were significantly higher as compared to the sepsis and the SIRS patients at baseline and on day 2. Moderate or high correlations among both the PCT and PRE values measured at baseline and on days 2, 4, and 7 were detected. Overall, the diagnostic and prognostic efficacies of PRE were comparable to those of PCT.Conclusions:During differential diagnosis, follow-up and prediction of mortality risk of patients for SIRS, sepsis and septic shock, findings of current study support that PRE possesses a merit to be used as a biomarker with comparable efficacy with PCT. |
| format | Article |
| id | doaj-art-b4792b22f1114dbc975b2ff73379b355 |
| institution | Kabale University |
| issn | 1302-0072 2147-2688 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj-art-b4792b22f1114dbc975b2ff73379b3552025-08-20T03:39:22ZengGalenos Publishing HouseHaseki Tıp Bülteni1302-00722147-26882020-03-0158220020710.4274/haseki.galenos.2020.601613049054Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortalityİbrahim Akkoç0Zümrüt Mine Işık Sağlam1Öznur Şen2Nurdan Aydın3Macit Koldaş4Mehmet Toptaş5Sinan Uzman6 University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Anesthesiology and Reanimation, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Medical Biochemistry, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Anesthesiology and Reanimation, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Anesthesiology and Reanimation, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Medical Biochemistry, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Anesthesiology and Reanimation, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Anesthesiology and Reanimation, İstanbul, Turkey Aim:We aimed to determine the efficacy of presepsin (PRE) as a biomarker of sepsis and to asssess its prognostic value for prediction of mortality were determined.Methods:Selected clinical data of 21 patients admitted to intensive care unit for systemic inflammatory response syndrome (SIRS), sepsis and septic shock were collected. APACHE-II score, blood culture results and WBC and CRP measured at baseline, procalcitonin (PCT) and PRE measured at baseline and on days 2, 4, and 7, and mortality of patients were recorded.Results:Compared to SIRS, sepsis and septic shock caused comparable increases in the APACHE II scores and mortality rates. The PRE values of the septic shock patients were significantly higher as compared to the sepsis and the SIRS patients at baseline and on day 2. Moderate or high correlations among both the PCT and PRE values measured at baseline and on days 2, 4, and 7 were detected. Overall, the diagnostic and prognostic efficacies of PRE were comparable to those of PCT.Conclusions:During differential diagnosis, follow-up and prediction of mortality risk of patients for SIRS, sepsis and septic shock, findings of current study support that PRE possesses a merit to be used as a biomarker with comparable efficacy with PCT. http://www.hasekidergisi.com/archives/archive-detail/article-preview/efficacy-of-presepsin-as-a-biomarker-of-sepsis-and/36511 systemic inflammatory response syndrome (sirs)sepsisseptic shockapache-iipresepsinprocalcitoninc-reactive protein (crp)white blood count (wbc) |
| spellingShingle | İbrahim Akkoç Zümrüt Mine Işık Sağlam Öznur Şen Nurdan Aydın Macit Koldaş Mehmet Toptaş Sinan Uzman Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortality Haseki Tıp Bülteni systemic inflammatory response syndrome (sirs) sepsis septic shock apache-ii presepsin procalcitonin c-reactive protein (crp) white blood count (wbc) |
| title | Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortality |
| title_full | Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortality |
| title_fullStr | Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortality |
| title_full_unstemmed | Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortality |
| title_short | Efficacy of Presepsin as a Biomarker of Sepsis and Its Prognostic Value for Prediction of Mortality |
| title_sort | efficacy of presepsin as a biomarker of sepsis and its prognostic value for prediction of mortality |
| topic | systemic inflammatory response syndrome (sirs) sepsis septic shock apache-ii presepsin procalcitonin c-reactive protein (crp) white blood count (wbc) |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/efficacy-of-presepsin-as-a-biomarker-of-sepsis-and/36511
|
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