Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021
Abstract Objective This study comprehensively examines the global burden of atrial fibrillation and atrial flutter (AF/AFL) attributable to high alcohol use from 1990 to 2021, analyzing temporal trends, regional disparities, and sociodemographic determinants using data from the Global Burden of Dise...
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BMC
2025-07-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04947-7 |
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| author | Xiaoming Wang Changzheng Chen Zhihua Yang Yu Chen Jun Fan Renchun Tang Yankun Shi Lixia Yang |
| author_facet | Xiaoming Wang Changzheng Chen Zhihua Yang Yu Chen Jun Fan Renchun Tang Yankun Shi Lixia Yang |
| author_sort | Xiaoming Wang |
| collection | DOAJ |
| description | Abstract Objective This study comprehensively examines the global burden of atrial fibrillation and atrial flutter (AF/AFL) attributable to high alcohol use from 1990 to 2021, analyzing temporal trends, regional disparities, and sociodemographic determinants using data from the Global Burden of Disease Study 2021 (GBD 2021). Methods We extracted GBD 2021 estimates on deaths, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) for AF/AFL due to high alcohol use across 204 countries. Joinpoint analysis and age-period-cohort (APC) modeling were employed to assess temporal trends and disentangle age, period, and cohort effects. Results In 2021, AF/AFL attributable to high alcohol use contributed to 11,908 deaths (95% UI: 8,860, 14,981) and 362,698 DALYs (95% UI: 263,321, 465,594) globally, marking increases of 176.4% and 132.9%, respectively, since 1990. While age-standardized death rates (ASDR) remained stable (0.2 per 100,000), males bore 2.3-fold higher mortality and 3.7-fold greater DALYs than females. Western Europe had the highest burden (4,589 deaths; 109,934 DALYs), while Oceania reported the lowest (2 deaths; 68 DALYs). High Socio-Demographic Index (SDI) regions exhibited the largest absolute burden, yet low-middle SDI regions experienced the steepest ASDR growth (estimated annual percentage change (EAPC) of ASDR is 2.01%). APC models revealed diverging sex-specific trends: male mortality marginally increased (net drift = 0.091%/year) versus significant female declines (–0.925%/year). The mortality rates are notably elevated in the age groups of 30–39 and those over 75 years, with the highest peak observed in individuals aged 95 and above. Conclusion AF/AFL attributable to high alcohol use remains a critical public health challenge, disproportionately affecting males, high-SDI regions, and aging populations. Targeted interventions addressing alcohol consumption patterns, gender-specific risk mitigation, and healthcare disparities are urgently needed to reduce the growing burden, particularly in regions with accelerating trends. |
| format | Article |
| id | doaj-art-b47742f65fdc4d4b85b0ff3d4d638658 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-b47742f65fdc4d4b85b0ff3d4d6386582025-08-24T11:06:49ZengBMCBMC Cardiovascular Disorders1471-22612025-07-0125111510.1186/s12872-025-04947-7Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021Xiaoming Wang0Changzheng Chen1Zhihua Yang2Yu Chen3Jun Fan4Renchun Tang5Yankun Shi6Lixia Yang7Department of Cardiovascular Medicine, 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyDepartment of Cardiovascular Medicine, 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyDepartment of Cardiovascular Medicine, 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyDepartment of Cardiovascular Medicine, 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyDepartment of Cardiovascular Medicine, 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyDepartment of Cardiovascular Medicine, 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyDepartment of Cardiovascular Medicine, 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyDepartment of Cardiovascular Medicine, 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyAbstract Objective This study comprehensively examines the global burden of atrial fibrillation and atrial flutter (AF/AFL) attributable to high alcohol use from 1990 to 2021, analyzing temporal trends, regional disparities, and sociodemographic determinants using data from the Global Burden of Disease Study 2021 (GBD 2021). Methods We extracted GBD 2021 estimates on deaths, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) for AF/AFL due to high alcohol use across 204 countries. Joinpoint analysis and age-period-cohort (APC) modeling were employed to assess temporal trends and disentangle age, period, and cohort effects. Results In 2021, AF/AFL attributable to high alcohol use contributed to 11,908 deaths (95% UI: 8,860, 14,981) and 362,698 DALYs (95% UI: 263,321, 465,594) globally, marking increases of 176.4% and 132.9%, respectively, since 1990. While age-standardized death rates (ASDR) remained stable (0.2 per 100,000), males bore 2.3-fold higher mortality and 3.7-fold greater DALYs than females. Western Europe had the highest burden (4,589 deaths; 109,934 DALYs), while Oceania reported the lowest (2 deaths; 68 DALYs). High Socio-Demographic Index (SDI) regions exhibited the largest absolute burden, yet low-middle SDI regions experienced the steepest ASDR growth (estimated annual percentage change (EAPC) of ASDR is 2.01%). APC models revealed diverging sex-specific trends: male mortality marginally increased (net drift = 0.091%/year) versus significant female declines (–0.925%/year). The mortality rates are notably elevated in the age groups of 30–39 and those over 75 years, with the highest peak observed in individuals aged 95 and above. Conclusion AF/AFL attributable to high alcohol use remains a critical public health challenge, disproportionately affecting males, high-SDI regions, and aging populations. Targeted interventions addressing alcohol consumption patterns, gender-specific risk mitigation, and healthcare disparities are urgently needed to reduce the growing burden, particularly in regions with accelerating trends.https://doi.org/10.1186/s12872-025-04947-7Atrial fibrillationHigh alcohol useGlobal burden of diseaseJoinpoint analysisAge-period-cohort model |
| spellingShingle | Xiaoming Wang Changzheng Chen Zhihua Yang Yu Chen Jun Fan Renchun Tang Yankun Shi Lixia Yang Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021 BMC Cardiovascular Disorders Atrial fibrillation High alcohol use Global burden of disease Joinpoint analysis Age-period-cohort model |
| title | Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021 |
| title_full | Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021 |
| title_fullStr | Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021 |
| title_full_unstemmed | Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021 |
| title_short | Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021 |
| title_sort | global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021 estimates from the global burden of disease study 2021 |
| topic | Atrial fibrillation High alcohol use Global burden of disease Joinpoint analysis Age-period-cohort model |
| url | https://doi.org/10.1186/s12872-025-04947-7 |
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