Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits
The present study aimed to investigate the effects of nano-capsulated ivermectin on the liver and kidney function and oxidative status in mite infested-rabbits, compared to ivermectin. Additionally, the ivermectin residue profile in adipose tissue, liver, muscle, and kidney was evaluated. For this p...
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| Language: | English |
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German Multidisciplinary Publishing Center (GMPC)
2022-01-01
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| Series: | German Journal of Veterinary Research |
| Online Access: | https://doi.org/10.51585/gjvr.2022.4.0043 |
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| author | Azza Abdelmoteleb Dalia Elmasry Fatma Amro Reham Mahmoud |
| author_facet | Azza Abdelmoteleb Dalia Elmasry Fatma Amro Reham Mahmoud |
| author_sort | Azza Abdelmoteleb |
| collection | DOAJ |
| description | The present study aimed to investigate the effects of nano-capsulated ivermectin on the liver and kidney function and oxidative status in mite infested-rabbits, compared to ivermectin. Additionally, the ivermectin residue profile in adipose tissue, liver, muscle, and kidney was evaluated. For this purpose, nano-capsulated ivermectin was prepared and characterized using high-resolution transmission electron microscopy (HRTEM) and cytotoxicity assay on Vero cells. To assess the effect of dose escalation of nano-capsulated ivermectin, one-hundred naturally mite-infested male rabbits were divided into four groups (G1-G4; n=25). Rabbits kept in G1 were left untreated (positive control), while rabbits kept in G2 and G3 received subcutaneously 200 and 400 μg/kg body weight ivermectin, respectively, at zero-day and repeated after two weeks of the first injection. Rabbits in G4 were treated with 200 μg/kg nano-capsulated ivermectin at zero day as a single dose. Additionally, twenty-five healthy male rabbits (G0) were used as a negative control. The efficacy was assessed based on clinical manifestations, liver and kidney function, and oxidative stress parameters. Ivermectin residues were measured in fat, liver, muscle, and kidney using high-performance liquid chromatography (HPLC). Results showed that the size of the nano-capsulated ivermectin was 35.4 nm with a narrow size distribution of 0.578 polydispersity indexes. A significant improvement in liver and kidney functions (P |
| format | Article |
| id | doaj-art-b4772e9675ea401daaa731e68c73ffd3 |
| institution | OA Journals |
| issn | 2703-1322 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | German Multidisciplinary Publishing Center (GMPC) |
| record_format | Article |
| series | German Journal of Veterinary Research |
| spelling | doaj-art-b4772e9675ea401daaa731e68c73ffd32025-08-20T02:02:40ZengGerman Multidisciplinary Publishing Center (GMPC)German Journal of Veterinary Research2703-13222022-01-0181510.51585/gjvr.2022.4.0043Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbitsAzza AbdelmotelebDalia ElmasryFatma AmroReham MahmoudThe present study aimed to investigate the effects of nano-capsulated ivermectin on the liver and kidney function and oxidative status in mite infested-rabbits, compared to ivermectin. Additionally, the ivermectin residue profile in adipose tissue, liver, muscle, and kidney was evaluated. For this purpose, nano-capsulated ivermectin was prepared and characterized using high-resolution transmission electron microscopy (HRTEM) and cytotoxicity assay on Vero cells. To assess the effect of dose escalation of nano-capsulated ivermectin, one-hundred naturally mite-infested male rabbits were divided into four groups (G1-G4; n=25). Rabbits kept in G1 were left untreated (positive control), while rabbits kept in G2 and G3 received subcutaneously 200 and 400 μg/kg body weight ivermectin, respectively, at zero-day and repeated after two weeks of the first injection. Rabbits in G4 were treated with 200 μg/kg nano-capsulated ivermectin at zero day as a single dose. Additionally, twenty-five healthy male rabbits (G0) were used as a negative control. The efficacy was assessed based on clinical manifestations, liver and kidney function, and oxidative stress parameters. Ivermectin residues were measured in fat, liver, muscle, and kidney using high-performance liquid chromatography (HPLC). Results showed that the size of the nano-capsulated ivermectin was 35.4 nm with a narrow size distribution of 0.578 polydispersity indexes. A significant improvement in liver and kidney functions (Phttps://doi.org/10.51585/gjvr.2022.4.0043 |
| spellingShingle | Azza Abdelmoteleb Dalia Elmasry Fatma Amro Reham Mahmoud Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits German Journal of Veterinary Research |
| title | Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits |
| title_full | Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits |
| title_fullStr | Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits |
| title_full_unstemmed | Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits |
| title_short | Comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits |
| title_sort | comparative effect of dose escalation of nanocapsulated ivermectin against mange in rabbits |
| url | https://doi.org/10.51585/gjvr.2022.4.0043 |
| work_keys_str_mv | AT azzaabdelmoteleb comparativeeffectofdoseescalationofnanocapsulatedivermectinagainstmangeinrabbits AT daliaelmasry comparativeeffectofdoseescalationofnanocapsulatedivermectinagainstmangeinrabbits AT fatmaamro comparativeeffectofdoseescalationofnanocapsulatedivermectinagainstmangeinrabbits AT rehammahmoud comparativeeffectofdoseescalationofnanocapsulatedivermectinagainstmangeinrabbits |