Progress in the application of novel inflammatory indicators in chronic kidney disease
Chronic kidney disease has become a public health problem endangering the health of all humans because of its high prevalence, high mortality and high medical burden. The chronic micro-inflammatory state is recognized as a significant component of CKD, playing a key role in disease progression. Inte...
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Frontiers Media S.A.
2025-01-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1500166/full |
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author | Wenrui Gao Wenrui Gao Xiangyu Wang Xiangyu Wang Yulin Zou Sheng Wang Jun Dou Senlin Qian |
author_facet | Wenrui Gao Wenrui Gao Xiangyu Wang Xiangyu Wang Yulin Zou Sheng Wang Jun Dou Senlin Qian |
author_sort | Wenrui Gao |
collection | DOAJ |
description | Chronic kidney disease has become a public health problem endangering the health of all humans because of its high prevalence, high mortality and high medical burden. The chronic micro-inflammatory state is recognized as a significant component of CKD, playing a key role in disease progression. Intervening in chronic inflammation during the disease course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such as the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index are closely associated with CKD, meanwhile may serve as prognostic monitors of all-cause death and poor renal prognosis for the disease. This article comprehensively reports on the mechanisms of micro-inflammation in CKD, the relationship between inflammatory indicators and CKD, and their impact on prognosis. |
format | Article |
id | doaj-art-b473b40615dd46ee994a1647546802e6 |
institution | Kabale University |
issn | 2296-858X |
language | English |
publishDate | 2025-01-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Medicine |
spelling | doaj-art-b473b40615dd46ee994a1647546802e62025-01-30T06:22:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15001661500166Progress in the application of novel inflammatory indicators in chronic kidney diseaseWenrui Gao0Wenrui Gao1Xiangyu Wang2Xiangyu Wang3Yulin Zou4Sheng Wang5Jun Dou6Senlin Qian7Department of Nephrology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaSchool of Basic Medicine, China Three Gorges University, Yichang, Hubei, ChinaSchool of Basic Medicine, China Three Gorges University, Yichang, Hubei, ChinaDepartment of Neurology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaDepartment of Geriatrics, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaDepartment of Clinical laboratory, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaDepartment of Nephrology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaDepartment of Nephrology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaChronic kidney disease has become a public health problem endangering the health of all humans because of its high prevalence, high mortality and high medical burden. The chronic micro-inflammatory state is recognized as a significant component of CKD, playing a key role in disease progression. Intervening in chronic inflammation during the disease course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such as the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index are closely associated with CKD, meanwhile may serve as prognostic monitors of all-cause death and poor renal prognosis for the disease. This article comprehensively reports on the mechanisms of micro-inflammation in CKD, the relationship between inflammatory indicators and CKD, and their impact on prognosis.https://www.frontiersin.org/articles/10.3389/fmed.2025.1500166/fullchronic kidney diseasemicro-inflammationneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiosystemic immune-inflammation indexrelationship |
spellingShingle | Wenrui Gao Wenrui Gao Xiangyu Wang Xiangyu Wang Yulin Zou Sheng Wang Jun Dou Senlin Qian Progress in the application of novel inflammatory indicators in chronic kidney disease Frontiers in Medicine chronic kidney disease micro-inflammation neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index relationship |
title | Progress in the application of novel inflammatory indicators in chronic kidney disease |
title_full | Progress in the application of novel inflammatory indicators in chronic kidney disease |
title_fullStr | Progress in the application of novel inflammatory indicators in chronic kidney disease |
title_full_unstemmed | Progress in the application of novel inflammatory indicators in chronic kidney disease |
title_short | Progress in the application of novel inflammatory indicators in chronic kidney disease |
title_sort | progress in the application of novel inflammatory indicators in chronic kidney disease |
topic | chronic kidney disease micro-inflammation neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index relationship |
url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1500166/full |
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