Progress in the application of novel inflammatory indicators in chronic kidney disease

Chronic kidney disease has become a public health problem endangering the health of all humans because of its high prevalence, high mortality and high medical burden. The chronic micro-inflammatory state is recognized as a significant component of CKD, playing a key role in disease progression. Inte...

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Main Authors: Wenrui Gao, Xiangyu Wang, Yulin Zou, Sheng Wang, Jun Dou, Senlin Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Medicine
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Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1500166/full
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author Wenrui Gao
Wenrui Gao
Xiangyu Wang
Xiangyu Wang
Yulin Zou
Sheng Wang
Jun Dou
Senlin Qian
author_facet Wenrui Gao
Wenrui Gao
Xiangyu Wang
Xiangyu Wang
Yulin Zou
Sheng Wang
Jun Dou
Senlin Qian
author_sort Wenrui Gao
collection DOAJ
description Chronic kidney disease has become a public health problem endangering the health of all humans because of its high prevalence, high mortality and high medical burden. The chronic micro-inflammatory state is recognized as a significant component of CKD, playing a key role in disease progression. Intervening in chronic inflammation during the disease course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such as the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index are closely associated with CKD, meanwhile may serve as prognostic monitors of all-cause death and poor renal prognosis for the disease. This article comprehensively reports on the mechanisms of micro-inflammation in CKD, the relationship between inflammatory indicators and CKD, and their impact on prognosis.
format Article
id doaj-art-b473b40615dd46ee994a1647546802e6
institution Kabale University
issn 2296-858X
language English
publishDate 2025-01-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Medicine
spelling doaj-art-b473b40615dd46ee994a1647546802e62025-01-30T06:22:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15001661500166Progress in the application of novel inflammatory indicators in chronic kidney diseaseWenrui Gao0Wenrui Gao1Xiangyu Wang2Xiangyu Wang3Yulin Zou4Sheng Wang5Jun Dou6Senlin Qian7Department of Nephrology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaSchool of Basic Medicine, China Three Gorges University, Yichang, Hubei, ChinaSchool of Basic Medicine, China Three Gorges University, Yichang, Hubei, ChinaDepartment of Neurology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaDepartment of Geriatrics, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaDepartment of Clinical laboratory, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaDepartment of Nephrology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaDepartment of Nephrology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, Hubei, ChinaChronic kidney disease has become a public health problem endangering the health of all humans because of its high prevalence, high mortality and high medical burden. The chronic micro-inflammatory state is recognized as a significant component of CKD, playing a key role in disease progression. Intervening in chronic inflammation during the disease course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such as the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index are closely associated with CKD, meanwhile may serve as prognostic monitors of all-cause death and poor renal prognosis for the disease. This article comprehensively reports on the mechanisms of micro-inflammation in CKD, the relationship between inflammatory indicators and CKD, and their impact on prognosis.https://www.frontiersin.org/articles/10.3389/fmed.2025.1500166/fullchronic kidney diseasemicro-inflammationneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiosystemic immune-inflammation indexrelationship
spellingShingle Wenrui Gao
Wenrui Gao
Xiangyu Wang
Xiangyu Wang
Yulin Zou
Sheng Wang
Jun Dou
Senlin Qian
Progress in the application of novel inflammatory indicators in chronic kidney disease
Frontiers in Medicine
chronic kidney disease
micro-inflammation
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
systemic immune-inflammation index
relationship
title Progress in the application of novel inflammatory indicators in chronic kidney disease
title_full Progress in the application of novel inflammatory indicators in chronic kidney disease
title_fullStr Progress in the application of novel inflammatory indicators in chronic kidney disease
title_full_unstemmed Progress in the application of novel inflammatory indicators in chronic kidney disease
title_short Progress in the application of novel inflammatory indicators in chronic kidney disease
title_sort progress in the application of novel inflammatory indicators in chronic kidney disease
topic chronic kidney disease
micro-inflammation
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
systemic immune-inflammation index
relationship
url https://www.frontiersin.org/articles/10.3389/fmed.2025.1500166/full
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