Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization
Nanoparticles represent a powerful class of materials for drug delivery, leveraging their small size for passive targeting through the enhanced permeability and retention effect in tumors. This universal approach in tumor targeting offers several advantages over free therapeutics, particularly when...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-05-01
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| Series: | Advanced NanoBiomed Research |
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| Online Access: | https://doi.org/10.1002/anbr.202400187 |
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| author | Sarah Spiewok Felicitas Jansen Jiaying Han Markus Lamla Max von Delius Christian Trautwein Laura De Laporte Alexander J. C. Kuehne |
| author_facet | Sarah Spiewok Felicitas Jansen Jiaying Han Markus Lamla Max von Delius Christian Trautwein Laura De Laporte Alexander J. C. Kuehne |
| author_sort | Sarah Spiewok |
| collection | DOAJ |
| description | Nanoparticles represent a powerful class of materials for drug delivery, leveraging their small size for passive targeting through the enhanced permeability and retention effect in tumors. This universal approach in tumor targeting offers several advantages over free therapeutics, particularly when combined with imaging capabilities. While a plethora of nanoparticles exist for various imaging techniques, the number of nanoparticles with therapeutic functions is much smaller, due to the synthetic challenges present for incorporation and release of an active drug. Herein, a strategy to transform the tyrosine kinase inhibitor lenvatinib into a polymerizable prodrug monomer is presented, enabling its incorporation into biodegradable polyimidazole‐based particles. This drug monomer is then polymerized and thus incorporated into the nanoparticles via direct arylation in a dispersion polymerization approach. The polyimidazole backbone allows for high drug loads of up to 90 wt%. Additionally, the photoacoustic properties of the polyimidazole nanoparticles are preserved after drug incorporation. Moreover, the backbone remains degradable upon exposure to hydrogen peroxide, facilitating drug release. This approach enables packaging of a drug, for which no prodrug approaches exist and which is therefore challenging to incorporate into particles due to limited functional groups. The result is a new theranostic nanoagent. |
| format | Article |
| id | doaj-art-b47318d42f9c4ad68e1b6b145d0a063c |
| institution | Kabale University |
| issn | 2699-9307 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj-art-b47318d42f9c4ad68e1b6b145d0a063c2025-08-20T03:53:06ZengWiley-VCHAdvanced NanoBiomed Research2699-93072025-05-0155n/an/a10.1002/anbr.202400187Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion PolymerizationSarah Spiewok0Felicitas Jansen1Jiaying Han2Markus Lamla3Max von Delius4Christian Trautwein5Laura De Laporte6Alexander J. C. Kuehne7Institute of Macromolecular and Organic Chemistry Ulm University Albert‐Einstein‐Allee 11 89081 Ulm GermanyInstitute of Macromolecular and Organic Chemistry Ulm University Albert‐Einstein‐Allee 11 89081 Ulm GermanyInstitute of Macromolecular and Organic Chemistry Ulm University Albert‐Einstein‐Allee 11 89081 Ulm GermanyInstitute of Macromolecular and Organic Chemistry Ulm University Albert‐Einstein‐Allee 11 89081 Ulm GermanyInsitute of Organic Chemistry Ulm University Albert‐Einstein‐Allee 11 89081 Ulm GermanyIfADo ‐ Leibniz Research Centre of Working Environment and Human Factors Ardeystr. 67 44139 Dortmund GermanyDWI–Leibniz Institute for Interactive Materials Forckenbeckstraße 50 52074 Aachen GermanyInstitute of Macromolecular and Organic Chemistry Ulm University Albert‐Einstein‐Allee 11 89081 Ulm GermanyNanoparticles represent a powerful class of materials for drug delivery, leveraging their small size for passive targeting through the enhanced permeability and retention effect in tumors. This universal approach in tumor targeting offers several advantages over free therapeutics, particularly when combined with imaging capabilities. While a plethora of nanoparticles exist for various imaging techniques, the number of nanoparticles with therapeutic functions is much smaller, due to the synthetic challenges present for incorporation and release of an active drug. Herein, a strategy to transform the tyrosine kinase inhibitor lenvatinib into a polymerizable prodrug monomer is presented, enabling its incorporation into biodegradable polyimidazole‐based particles. This drug monomer is then polymerized and thus incorporated into the nanoparticles via direct arylation in a dispersion polymerization approach. The polyimidazole backbone allows for high drug loads of up to 90 wt%. Additionally, the photoacoustic properties of the polyimidazole nanoparticles are preserved after drug incorporation. Moreover, the backbone remains degradable upon exposure to hydrogen peroxide, facilitating drug release. This approach enables packaging of a drug, for which no prodrug approaches exist and which is therefore challenging to incorporate into particles due to limited functional groups. The result is a new theranostic nanoagent.https://doi.org/10.1002/anbr.202400187conjugated polymersdrug deliverieskinase inhibitorsphotoacoustic imagings |
| spellingShingle | Sarah Spiewok Felicitas Jansen Jiaying Han Markus Lamla Max von Delius Christian Trautwein Laura De Laporte Alexander J. C. Kuehne Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization Advanced NanoBiomed Research conjugated polymers drug deliveries kinase inhibitors photoacoustic imagings |
| title | Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization |
| title_full | Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization |
| title_fullStr | Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization |
| title_full_unstemmed | Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization |
| title_short | Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization |
| title_sort | highly loaded reactive oxygen species responsive theranostic lenvatinib prodrug nanoparticles produced by dispersion polymerization |
| topic | conjugated polymers drug deliveries kinase inhibitors photoacoustic imagings |
| url | https://doi.org/10.1002/anbr.202400187 |
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