Differential methylation of circulating free DNA assessed through cfMeDiP as a new tool for breast cancer diagnosis and detection of BRCA1/2 mutation

Differential methylation of circulating free DNA assessed through cfMeDiP as a new tool for breast cancer diagnosis and detection of BRCA1/2 mutation

Abstract Background Recent studies have highlighted the importance of the cell-free DNA (cfDNA) methylation profile in detecting breast cancer (BC) and its different subtypes. We investigated whether plasma cfDNA methylation, using cell-free Methylated DNA Immunoprecipitation and High-Throughput Seq...

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Bibliographic Details
Main Authors: Piera Grisolia, Rossella Tufano, Clara Iannarone, Antonio De Falco, Francesca Carlino, Cinzia Graziano, Raffaele Addeo, Marianna Scrima, Francesco Caraglia, Anna Ceccarelli, Pier Vitale Nuzzo, Alessia Maria Cossu, Stefano Forte, Raffaella Giuffrida, Michele Orditura, Michele Caraglia, Michele Ceccarelli
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Translational Medicine
Subjects:
Breast cancer
Cell-free DNA
DMRs
cfMeDIP-seq
BRCA1
BRCA2
Online Access:https://doi.org/10.1186/s12967-024-05734-2
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