Development and Characterization of a Nanocomposed Pioglitazone Hydrochloride-Loaded Niosomal Suspension for Targeted Drug Delivery
Background: The primary aim of this research was to address the significant challenge of low and unpredictable drug absorption following oral administration, which often occurs due to poor water solubility. Niosomes, which are lipid-based vesicles, have been explored as potential solutions to increa...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2025-01-01
|
| Series: | Journal of Bio-X Research |
| Online Access: | https://spj.science.org/doi/10.34133/jbioxresearch.0053 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850043715074129920 |
|---|---|
| author | Shweta Kyadalwar Rahul Waghmare Kranti Satpute Prakash Shivnechari Shoaeb Mohammad Syed |
| author_facet | Shweta Kyadalwar Rahul Waghmare Kranti Satpute Prakash Shivnechari Shoaeb Mohammad Syed |
| author_sort | Shweta Kyadalwar |
| collection | DOAJ |
| description | Background: The primary aim of this research was to address the significant challenge of low and unpredictable drug absorption following oral administration, which often occurs due to poor water solubility. Niosomes, which are lipid-based vesicles, have been explored as potential solutions to increase the solubility of water-insoluble drugs. Methods: Niosomal suspensions were prepared with the thin-film hydration method. Various concentrations of Span 20, Span 40, Tween 60, and cholesterol were used to optimize the formulation. The resulting formulations were characterized, and their properties were assessed. Results: The optimal formulation, namely, NS6, which was composed of Span 40 (200 mg) and cholesterol (40 mg), had a size of 206.1 nm and a zeta potential of −36.5 mV. Adjusting the surfactant concentration resulted in a maximum drug entrapment efficiency of 88.89%. Statistical analysis confirmed that NS6 was the optimal formulation. Conclusion: This study demonstrates that niosomal suspensions are promising drug delivery systems with potential for use in treating type 2 diabetes. Niosomes facilitate the sustained release and enhanced solubility of drugs, rendering them convenient and effective tools for enhancing drug delivery to target sites. |
| format | Article |
| id | doaj-art-b46bb44694e2499488d9ee8dbb3e8746 |
| institution | DOAJ |
| issn | 2577-3585 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Journal of Bio-X Research |
| spelling | doaj-art-b46bb44694e2499488d9ee8dbb3e87462025-08-20T02:55:09ZengAmerican Association for the Advancement of Science (AAAS)Journal of Bio-X Research2577-35852025-01-01810.34133/jbioxresearch.0053Development and Characterization of a Nanocomposed Pioglitazone Hydrochloride-Loaded Niosomal Suspension for Targeted Drug DeliveryShweta Kyadalwar0Rahul Waghmare1Kranti Satpute2Prakash Shivnechari3Shoaeb Mohammad Syed4Department of Pharmaceutics, Dayanand Education Society’s Dayanand College of Pharmacy, Latur, Maharashtra 413512, India.Department of Pharmaceutics, Dayanand Education Society’s Dayanand College of Pharmacy, Latur, Maharashtra 413512, India.Department of Quality Assurance, Dayanand Education Society’s Dayanand College of Pharmacy, Latur, Maharashtra 413512, India.Department of Pharmaceutics, Dayanand Education Society’s Dayanand College of Pharmacy, Latur, Maharashtra 413512, India.Department of Pharmaceutics, Dayanand Education Society’s Dayanand College of Pharmacy, Latur, Maharashtra 413512, India.Background: The primary aim of this research was to address the significant challenge of low and unpredictable drug absorption following oral administration, which often occurs due to poor water solubility. Niosomes, which are lipid-based vesicles, have been explored as potential solutions to increase the solubility of water-insoluble drugs. Methods: Niosomal suspensions were prepared with the thin-film hydration method. Various concentrations of Span 20, Span 40, Tween 60, and cholesterol were used to optimize the formulation. The resulting formulations were characterized, and their properties were assessed. Results: The optimal formulation, namely, NS6, which was composed of Span 40 (200 mg) and cholesterol (40 mg), had a size of 206.1 nm and a zeta potential of −36.5 mV. Adjusting the surfactant concentration resulted in a maximum drug entrapment efficiency of 88.89%. Statistical analysis confirmed that NS6 was the optimal formulation. Conclusion: This study demonstrates that niosomal suspensions are promising drug delivery systems with potential for use in treating type 2 diabetes. Niosomes facilitate the sustained release and enhanced solubility of drugs, rendering them convenient and effective tools for enhancing drug delivery to target sites.https://spj.science.org/doi/10.34133/jbioxresearch.0053 |
| spellingShingle | Shweta Kyadalwar Rahul Waghmare Kranti Satpute Prakash Shivnechari Shoaeb Mohammad Syed Development and Characterization of a Nanocomposed Pioglitazone Hydrochloride-Loaded Niosomal Suspension for Targeted Drug Delivery Journal of Bio-X Research |
| title | Development and Characterization of a Nanocomposed Pioglitazone Hydrochloride-Loaded Niosomal Suspension for Targeted Drug Delivery |
| title_full | Development and Characterization of a Nanocomposed Pioglitazone Hydrochloride-Loaded Niosomal Suspension for Targeted Drug Delivery |
| title_fullStr | Development and Characterization of a Nanocomposed Pioglitazone Hydrochloride-Loaded Niosomal Suspension for Targeted Drug Delivery |
| title_full_unstemmed | Development and Characterization of a Nanocomposed Pioglitazone Hydrochloride-Loaded Niosomal Suspension for Targeted Drug Delivery |
| title_short | Development and Characterization of a Nanocomposed Pioglitazone Hydrochloride-Loaded Niosomal Suspension for Targeted Drug Delivery |
| title_sort | development and characterization of a nanocomposed pioglitazone hydrochloride loaded niosomal suspension for targeted drug delivery |
| url | https://spj.science.org/doi/10.34133/jbioxresearch.0053 |
| work_keys_str_mv | AT shwetakyadalwar developmentandcharacterizationofananocomposedpioglitazonehydrochlorideloadedniosomalsuspensionfortargeteddrugdelivery AT rahulwaghmare developmentandcharacterizationofananocomposedpioglitazonehydrochlorideloadedniosomalsuspensionfortargeteddrugdelivery AT krantisatpute developmentandcharacterizationofananocomposedpioglitazonehydrochlorideloadedniosomalsuspensionfortargeteddrugdelivery AT prakashshivnechari developmentandcharacterizationofananocomposedpioglitazonehydrochlorideloadedniosomalsuspensionfortargeteddrugdelivery AT shoaebmohammadsyed developmentandcharacterizationofananocomposedpioglitazonehydrochlorideloadedniosomalsuspensionfortargeteddrugdelivery |