Pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitis
Aim. Immunohistochemical determination of cell proliferation and apoptosis processes in PanIN in ductal adenocarcinoma (DA) and chronic pancreatitis (CP). Materials and methods. Comprehensive histological, histochemical and immunohistochemical (IHC) study was carried out on the biopsy-postoperati...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2014-08-01
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| Series: | Patologìâ |
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| Online Access: | http://pat.zsmu.edu.ua/article/view/28590/25580 |
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| author | V. A. Tumanskiy A. V. Evseyev I. S. Kovalenko |
| author_facet | V. A. Tumanskiy A. V. Evseyev I. S. Kovalenko |
| author_sort | V. A. Tumanskiy |
| collection | DOAJ |
| description | Aim. Immunohistochemical determination of cell proliferation and apoptosis processes in PanIN in ductal adenocarcinoma (DA)
and chronic pancreatitis (CP).
Materials and methods. Comprehensive histological, histochemical and immunohistochemical (IHC) study was carried out on the
biopsy-postoperative material of 36 patients with CP with severe fi brosis of the pancreas, as well as 80 patients with DA.
Results. Reliable differences were shown in evidence of these processes in the zones of pancreatic intraepithelial neoplasia (PanIN)
in carcinoma and pancreatitis, and also depending on the stage of PanIN. Thus, in chronic pancreatitis and pancreatic carcinoma cell
proliferation average index in PanIN-1 was 0,75±0,46 and 0,96±0,42 points respectively, and in PanIN-2 – 1,39±0,64 and 2,2±0,8 points
respectively. It testifi es that level of proliferation and apoptosis processes in PanIN in patients with pancreatic ductal adenocarcinoma is higher, than in patients with chronic pancreatitis. |
| format | Article |
| id | doaj-art-b46629d47bf540bca998e2202bfd412e |
| institution | Kabale University |
| issn | 2306-8027 2310-1237 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Patologìâ |
| spelling | doaj-art-b46629d47bf540bca998e2202bfd412e2025-08-20T03:39:22ZengZaporizhzhia State Medical and Pharmaceutical UniversityPatologìâ2306-80272310-12372014-08-012707310.14739/2310-1237.2014.2.28590Pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitisV. A. TumanskiyA. V. Evseyev I. S. KovalenkoAim. Immunohistochemical determination of cell proliferation and apoptosis processes in PanIN in ductal adenocarcinoma (DA) and chronic pancreatitis (CP). Materials and methods. Comprehensive histological, histochemical and immunohistochemical (IHC) study was carried out on the biopsy-postoperative material of 36 patients with CP with severe fi brosis of the pancreas, as well as 80 patients with DA. Results. Reliable differences were shown in evidence of these processes in the zones of pancreatic intraepithelial neoplasia (PanIN) in carcinoma and pancreatitis, and also depending on the stage of PanIN. Thus, in chronic pancreatitis and pancreatic carcinoma cell proliferation average index in PanIN-1 was 0,75±0,46 and 0,96±0,42 points respectively, and in PanIN-2 – 1,39±0,64 and 2,2±0,8 points respectively. It testifi es that level of proliferation and apoptosis processes in PanIN in patients with pancreatic ductal adenocarcinoma is higher, than in patients with chronic pancreatitis.http://pat.zsmu.edu.ua/article/view/28590/25580NeoplasmsCarcinomaPancreatitisApoptosis. |
| spellingShingle | V. A. Tumanskiy A. V. Evseyev I. S. Kovalenko Pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitis Patologìâ Neoplasms Carcinoma Pancreatitis Apoptosis. |
| title | Pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitis |
| title_full | Pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitis |
| title_fullStr | Pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitis |
| title_full_unstemmed | Pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitis |
| title_short | Pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitis |
| title_sort | pathomorphological description of proliferation and apoptosis processes in pancreatic intraepithelial neoplasia in the pancreatic ductal adenocarcinoma and chronic pancreatitis |
| topic | Neoplasms Carcinoma Pancreatitis Apoptosis. |
| url | http://pat.zsmu.edu.ua/article/view/28590/25580 |
| work_keys_str_mv | AT vatumanskiy pathomorphologicaldescriptionofproliferationandapoptosisprocessesinpancreaticintraepithelialneoplasiainthepancreaticductaladenocarcinomaandchronicpancreatitis AT avevseyev pathomorphologicaldescriptionofproliferationandapoptosisprocessesinpancreaticintraepithelialneoplasiainthepancreaticductaladenocarcinomaandchronicpancreatitis AT iskovalenko pathomorphologicaldescriptionofproliferationandapoptosisprocessesinpancreaticintraepithelialneoplasiainthepancreaticductaladenocarcinomaandchronicpancreatitis |