Dual antioxidant and cytotoxic activities of novel 1,2,3-triazole-decorated unsymmetrical monocarbonyl curcumin analogs

Dual antioxidant and cytotoxic activities of novel 1,2,3-triazole-decorated unsymmetrical monocarbonyl curcumin analogs

Unsymmetrical monocarbonyl curcumin analogs containing 1,2,3-triazole scaffold (5a-5f) have been synthesized from vanillin. 5d, which contains a carboxylic group, exhibited the highest antioxidant and cytotoxic activities, with an IC50 of 0.56 mM against DPPH and an IC50 of 38.25 ± 4.79 μM against M...

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Bibliographic Details
Main Authors: Bayu Ardiansah, Ahmad Farhan, Novita Sari Nurhasanah, Mochammad Arfin Fardiansyah Nasution, Noordini M. Salleh, Kenji Mizuguchi, Antonius Herry Cahyana, Lina Mardiana
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Case Studies in Chemical and Environmental Engineering
Subjects:
Curcumin analogs
1,2,3-triazole
Hybrid compounds
Cytotoxic
Antioxidant
Online Access:http://www.sciencedirect.com/science/article/pii/S2666016424004250
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