Impact of High Glucose on Bone Collagenous Matrix Composition, Structure, and Organization: An Integrative Analysis Using an Ex Vivo Model

Impact of High Glucose on Bone Collagenous Matrix Composition, Structure, and Organization: An Integrative Analysis Using an Ex Vivo Model

Diabetes mellitus is a widespread metabolic disorder linked to numerous systemic complications, including adverse effects on skeletal health, such as increased bone fragility and fracture risk. Emerging evidence suggests that high glucose may disrupt the extracellular matrix (ECM) of bone, potential...

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Bibliographic Details
Main Authors: Rita Araújo, Ricardo N. M. J. Páscoa, Raquel Bernardino, Pedro S. Gomes
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
diabetes mellitus
bone tissue
extracellular matrix (ECM)
collagen
ex vivo model
FTIR
Online Access:https://www.mdpi.com/2073-4409/14/2/130
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