Multimodal Imaging Features of Schnyder Corneal Dystrophy
Objective. To describe the multimodal imaging of Schnyder corneal dystrophy. Methods. Seven eyes of seven patients (5 female and 2 male patients) aged 52 to 92 years were included in this prospective observational study. Diagnosis of SCD was confirmed by histology after keratoplasty. In vivo multimo...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2020/6701816 |
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| author | Wassim Ghazal Cristina Georgeon Kate Grieve Nacim Bouheraoua Vincent Borderie |
| author_facet | Wassim Ghazal Cristina Georgeon Kate Grieve Nacim Bouheraoua Vincent Borderie |
| author_sort | Wassim Ghazal |
| collection | DOAJ |
| description | Objective. To describe the multimodal imaging of Schnyder corneal dystrophy. Methods. Seven eyes of seven patients (5 female and 2 male patients) aged 52 to 92 years were included in this prospective observational study. Diagnosis of SCD was confirmed by histology after keratoplasty. In vivo multimodal imaging consisted of spectral domain-optical coherence tomography with cross sections, en face scans, corneal pachymetry, and epithelial mapping, and in vivo confocal microscopy was recorded. Ex vivo full-field optical coherence tomography scans of two corneal buttons were analyzed. The seven corneal buttons obtained during penetrating or deep anterior lamellar keratoplasty were processed for light microscopy. Results. Slit-lamp examination showed central stromal opacities, arcus lipoides, and midperipheral haze. Corneal crystals were found in 2 out of 7 eyes. SD-OCT cross sections and en face scans showed diffuse hyperreflectivity of the anterior, mid, and posterior stroma with a maximum in the anterior stroma, hyporeflective stromal striae, and epithelial hyperreflectivity. Central corneal thickness ranged from 507 to 635 μm. IVCM revealed hyperreflective deposits in the epithelium and throughout the stroma, thin subepithelial nerves, and needle-shaped and rectangular crystals. Keratocyte nuclei were rare or undetectable. FF-OCT scans confirmed the presence of small round and needle-shaped hyperreflective deposits in the epithelium and stroma. Histology revealed vacuolization of the basal epithelial cells and empty interlamellar stromal vacuoles. Conclusion. High-resolution multimodal imaging demonstrates the characteristic features of SCD which involve both the corneal epithelium and stroma, and it provides diagnosis confirmation even in eyes with no visible corneal crystals at slit-lamp examination. |
| format | Article |
| id | doaj-art-b4559b495b4941e7a2245c2c2acf2df4 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-b4559b495b4941e7a2245c2c2acf2df42025-08-20T02:23:12ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/67018166701816Multimodal Imaging Features of Schnyder Corneal DystrophyWassim Ghazal0Cristina Georgeon1Kate Grieve2Nacim Bouheraoua3Vincent Borderie4Centre Hospitalier National d’Ophtalmologie des 15-20, Paris, FranceCentre Hospitalier National d’Ophtalmologie des 15-20, Paris, FranceCentre Hospitalier National d’Ophtalmologie des 15-20, Paris, FranceCentre Hospitalier National d’Ophtalmologie des 15-20, Paris, FranceCentre Hospitalier National d’Ophtalmologie des 15-20, Paris, FranceObjective. To describe the multimodal imaging of Schnyder corneal dystrophy. Methods. Seven eyes of seven patients (5 female and 2 male patients) aged 52 to 92 years were included in this prospective observational study. Diagnosis of SCD was confirmed by histology after keratoplasty. In vivo multimodal imaging consisted of spectral domain-optical coherence tomography with cross sections, en face scans, corneal pachymetry, and epithelial mapping, and in vivo confocal microscopy was recorded. Ex vivo full-field optical coherence tomography scans of two corneal buttons were analyzed. The seven corneal buttons obtained during penetrating or deep anterior lamellar keratoplasty were processed for light microscopy. Results. Slit-lamp examination showed central stromal opacities, arcus lipoides, and midperipheral haze. Corneal crystals were found in 2 out of 7 eyes. SD-OCT cross sections and en face scans showed diffuse hyperreflectivity of the anterior, mid, and posterior stroma with a maximum in the anterior stroma, hyporeflective stromal striae, and epithelial hyperreflectivity. Central corneal thickness ranged from 507 to 635 μm. IVCM revealed hyperreflective deposits in the epithelium and throughout the stroma, thin subepithelial nerves, and needle-shaped and rectangular crystals. Keratocyte nuclei were rare or undetectable. FF-OCT scans confirmed the presence of small round and needle-shaped hyperreflective deposits in the epithelium and stroma. Histology revealed vacuolization of the basal epithelial cells and empty interlamellar stromal vacuoles. Conclusion. High-resolution multimodal imaging demonstrates the characteristic features of SCD which involve both the corneal epithelium and stroma, and it provides diagnosis confirmation even in eyes with no visible corneal crystals at slit-lamp examination.http://dx.doi.org/10.1155/2020/6701816 |
| spellingShingle | Wassim Ghazal Cristina Georgeon Kate Grieve Nacim Bouheraoua Vincent Borderie Multimodal Imaging Features of Schnyder Corneal Dystrophy Journal of Ophthalmology |
| title | Multimodal Imaging Features of Schnyder Corneal Dystrophy |
| title_full | Multimodal Imaging Features of Schnyder Corneal Dystrophy |
| title_fullStr | Multimodal Imaging Features of Schnyder Corneal Dystrophy |
| title_full_unstemmed | Multimodal Imaging Features of Schnyder Corneal Dystrophy |
| title_short | Multimodal Imaging Features of Schnyder Corneal Dystrophy |
| title_sort | multimodal imaging features of schnyder corneal dystrophy |
| url | http://dx.doi.org/10.1155/2020/6701816 |
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