Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophrenia
Introduction. Drug-induced dyskinesia is an iatrogenic undesirable side reaction from the extrapyramidal system that occurs during the administration of drugs, most often antipsychotics in patients with schizophrenia. At the end of the 20 th century, studies were conducted on the search for candidat...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2020-12-01
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| Series: | Нервно-мышечные болезни |
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| Online Access: | https://nmb.abvpress.ru/jour/article/view/394 |
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| author | E. E. Vaiman N. A. Shnayder N. G. Neznanov R. F. Nasyrova |
| author_facet | E. E. Vaiman N. A. Shnayder N. G. Neznanov R. F. Nasyrova |
| author_sort | E. E. Vaiman |
| collection | DOAJ |
| description | Introduction. Drug-induced dyskinesia is an iatrogenic undesirable side reaction from the extrapyramidal system that occurs during the administration of drugs, most often antipsychotics in patients with schizophrenia. At the end of the 20 th century, studies were conducted on the search for candidate genes and the carriage of single nucleotide variants of antipsychotics-induced tardive dyskinesia. Purpose of the study – to analyze research results reflecting candidate genes and their single nucleotide variants associated with antipsychotic-induced tardive dyskinesia. Materials and methods. We searched for full-text publications in Russian and English in the eLIBRARY, PubMed, Web of Science, Springer databases using keywords (tardive dyskinesia, drug-induced tardive dyskinesia, antipsychotics, antipsychotics, typical antipsychotics, atypical antipsychotics, genes, polymorphisms) and combined searches for words over the past decade. Results. The lecture discusses candidate genes encoding proteins/enzymes involved in the pharmacodynamics and pharmacokinetics of antipsychotics Conclusion. Timely identification of individual genetic characteristics of the patient can contribute to the development of diagnostic test systems and in the future selection of the safest and most effective antipsychotic therapy. |
| format | Article |
| id | doaj-art-b4556741a30849c8ba80abf5d20a52ee |
| institution | DOAJ |
| issn | 2222-8721 2413-0443 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Нервно-мышечные болезни |
| spelling | doaj-art-b4556741a30849c8ba80abf5d20a52ee2025-08-20T03:00:40ZrusABV-pressНервно-мышечные болезни2222-87212413-04432020-12-01103102610.17650/2222-8721-2020-10-3-10-26273Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophreniaE. E. Vaiman0N. A. Shnayder1N. G. Neznanov2R. F. Nasyrova3National Medical Research Center of Psychiatry and Neurology named after V.M. Bekhterev, the Ministry of Health of RussiaNational Medical Research Center of Psychiatry and Neurology named after V.M. Bekhterev, the Ministry of Health of RussiaNational Medical Research Center of Psychiatry and Neurology named after V.M. Bekhterev, the Ministry of Health of RussiaNational Medical Research Center of Psychiatry and Neurology named after V.M. Bekhterev, the Ministry of Health of RussiaIntroduction. Drug-induced dyskinesia is an iatrogenic undesirable side reaction from the extrapyramidal system that occurs during the administration of drugs, most often antipsychotics in patients with schizophrenia. At the end of the 20 th century, studies were conducted on the search for candidate genes and the carriage of single nucleotide variants of antipsychotics-induced tardive dyskinesia. Purpose of the study – to analyze research results reflecting candidate genes and their single nucleotide variants associated with antipsychotic-induced tardive dyskinesia. Materials and methods. We searched for full-text publications in Russian and English in the eLIBRARY, PubMed, Web of Science, Springer databases using keywords (tardive dyskinesia, drug-induced tardive dyskinesia, antipsychotics, antipsychotics, typical antipsychotics, atypical antipsychotics, genes, polymorphisms) and combined searches for words over the past decade. Results. The lecture discusses candidate genes encoding proteins/enzymes involved in the pharmacodynamics and pharmacokinetics of antipsychotics Conclusion. Timely identification of individual genetic characteristics of the patient can contribute to the development of diagnostic test systems and in the future selection of the safest and most effective antipsychotic therapy.https://nmb.abvpress.ru/jour/article/view/394tardive dyskinesiadrug-induced tardive dyskinesiaantipsychoticsgenes |
| spellingShingle | E. E. Vaiman N. A. Shnayder N. G. Neznanov R. F. Nasyrova Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophrenia Нервно-мышечные болезни tardive dyskinesia drug-induced tardive dyskinesia antipsychotics genes |
| title | Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophrenia |
| title_full | Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophrenia |
| title_fullStr | Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophrenia |
| title_full_unstemmed | Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophrenia |
| title_short | Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophrenia |
| title_sort | candidate genes involved in the development of antipsychotic induced tardive dyskinesia in patients with schizophrenia |
| topic | tardive dyskinesia drug-induced tardive dyskinesia antipsychotics genes |
| url | https://nmb.abvpress.ru/jour/article/view/394 |
| work_keys_str_mv | AT eevaiman candidategenesinvolvedinthedevelopmentofantipsychoticinducedtardivedyskinesiainpatientswithschizophrenia AT nashnayder candidategenesinvolvedinthedevelopmentofantipsychoticinducedtardivedyskinesiainpatientswithschizophrenia AT ngneznanov candidategenesinvolvedinthedevelopmentofantipsychoticinducedtardivedyskinesiainpatientswithschizophrenia AT rfnasyrova candidategenesinvolvedinthedevelopmentofantipsychoticinducedtardivedyskinesiainpatientswithschizophrenia |