Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003–2004
Brominated flame retardants (BFRs) represent a group of synthetic chemical compounds that have been ubiquitously incorporated into numerous consumer products. Human exposure to BFRs occurs through multiple routes, posing potential health risks. However, the association between BFR exposure and hyper...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325012102 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849339417136726016 |
|---|---|
| author | Yiqian Wang Xianhao Wang Yingqi Yan Zihui Zhao Ruxu Yan Yuming Zhang Meng Liu Xianfeng Yue Qingqing Wu Xin Ma Hongchen Jiang Long Ji Xuezhen Zhao Min Sun Jianhong Qiao Dong Li |
| author_facet | Yiqian Wang Xianhao Wang Yingqi Yan Zihui Zhao Ruxu Yan Yuming Zhang Meng Liu Xianfeng Yue Qingqing Wu Xin Ma Hongchen Jiang Long Ji Xuezhen Zhao Min Sun Jianhong Qiao Dong Li |
| author_sort | Yiqian Wang |
| collection | DOAJ |
| description | Brominated flame retardants (BFRs) represent a group of synthetic chemical compounds that have been ubiquitously incorporated into numerous consumer products. Human exposure to BFRs occurs through multiple routes, posing potential health risks. However, the association between BFR exposure and hyperuricemia and the role of lipid dysregulation remain unexplored. Data from 1171 respondents to the National Health and Nutrition Examination Survey (NHANES) survey cycle of 2003–2004 were used. We investigated the risk of hyperuricemia (HUA) from mixed BFR exposure using weighted quantile sum (WQS), quantile g-computation (Qgcomp), Bayesian kernel machine regression (BKMR), Elastic Net (ENET), and decision tree classifier (DT) models. The models were interpreted using Shapley Additive exPlanations (SHAP). Our results indicate that the weights of BDE-28, BDE-47, and BDE-99 are higher than those of the other BFR congeners analyzed. Total cholesterol (TC) was found to mediate the effects of BDE-28, BDE-47, and BDE-99 on hyperuricemia, with mediation proportions of 10.11 %, 10.10 %, and 9.55 %, respectively. Functional enrichment analyses revealed significant enrichment in lipid and atherosclerosis pathways. According to our findings, exposure to BFRs fosters hyperuricemia, and dysregulated lipid metabolism is a major contributing factor to this relationship. |
| format | Article |
| id | doaj-art-b451ce9b4dcf4d64bc94709b00e557f7 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-b451ce9b4dcf4d64bc94709b00e557f72025-08-20T03:44:07ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130311886510.1016/j.ecoenv.2025.118865Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003–2004Yiqian Wang0Xianhao Wang1Yingqi Yan2Zihui Zhao3Ruxu Yan4Yuming Zhang5Meng Liu6Xianfeng Yue7Qingqing Wu8Xin Ma9Hongchen Jiang10Long Ji11Xuezhen Zhao12Min Sun13Jianhong Qiao14Dong Li15School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; School of Public Health, Jining Medical University, Jining 272067, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, ChinaSchool of Nursing, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China; The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; School of Public Health, Jining Medical University, Jining 272067, ChinaThe First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, China; School of Nursing and Rehabilitation, Shandong University, Jinan 250012, ChinaSchool of Nursing, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China; The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; School of Sports Medicine and Rehabilitation, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, ChinaDepartment of Pharmacy, Shandong Provincial Maternal and Child Health Care Hospital, Jinan 250014, China; Corresponding authors.The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, China; School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; Corresponding author at: The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250014, China.School of Public Health, Jining Medical University, Jining 272067, China; Corresponding authors.Brominated flame retardants (BFRs) represent a group of synthetic chemical compounds that have been ubiquitously incorporated into numerous consumer products. Human exposure to BFRs occurs through multiple routes, posing potential health risks. However, the association between BFR exposure and hyperuricemia and the role of lipid dysregulation remain unexplored. Data from 1171 respondents to the National Health and Nutrition Examination Survey (NHANES) survey cycle of 2003–2004 were used. We investigated the risk of hyperuricemia (HUA) from mixed BFR exposure using weighted quantile sum (WQS), quantile g-computation (Qgcomp), Bayesian kernel machine regression (BKMR), Elastic Net (ENET), and decision tree classifier (DT) models. The models were interpreted using Shapley Additive exPlanations (SHAP). Our results indicate that the weights of BDE-28, BDE-47, and BDE-99 are higher than those of the other BFR congeners analyzed. Total cholesterol (TC) was found to mediate the effects of BDE-28, BDE-47, and BDE-99 on hyperuricemia, with mediation proportions of 10.11 %, 10.10 %, and 9.55 %, respectively. Functional enrichment analyses revealed significant enrichment in lipid and atherosclerosis pathways. According to our findings, exposure to BFRs fosters hyperuricemia, and dysregulated lipid metabolism is a major contributing factor to this relationship.http://www.sciencedirect.com/science/article/pii/S0147651325012102Brominated flame retardantsHyperuricemiaDysregulated lipid metabolismFunctional enrichment analyses |
| spellingShingle | Yiqian Wang Xianhao Wang Yingqi Yan Zihui Zhao Ruxu Yan Yuming Zhang Meng Liu Xianfeng Yue Qingqing Wu Xin Ma Hongchen Jiang Long Ji Xuezhen Zhao Min Sun Jianhong Qiao Dong Li Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003–2004 Ecotoxicology and Environmental Safety Brominated flame retardants Hyperuricemia Dysregulated lipid metabolism Functional enrichment analyses |
| title | Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003–2004 |
| title_full | Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003–2004 |
| title_fullStr | Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003–2004 |
| title_full_unstemmed | Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003–2004 |
| title_short | Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003–2004 |
| title_sort | dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia evidence from nhanes 2003 2004 |
| topic | Brominated flame retardants Hyperuricemia Dysregulated lipid metabolism Functional enrichment analyses |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325012102 |
| work_keys_str_mv | AT yiqianwang dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT xianhaowang dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT yingqiyan dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT zihuizhao dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT ruxuyan dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT yumingzhang dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT mengliu dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT xianfengyue dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT qingqingwu dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT xinma dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT hongchenjiang dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT longji dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT xuezhenzhao dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT minsun dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT jianhongqiao dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 AT dongli dysregulatedlipidmetabolismmediatestheassociationbetweenbrominatedflameretardantexposureandhyperuricemiaevidencefromnhanes20032004 |