Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy
Abstract The repair of osteoporotic bone defects remains inadequately addressed, primarily due to a disruption in bone homeostasis, characterized by insufficient bone formation and excessive bone resorption. Current research either focuses on promoting bone formation or inhibiting bone resorption, h...
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202504293 |
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| author | Xinhui Wu Tianlong Wang Jinhui Zhao Lei Zhang Zhiqing Liu Yixing Chen Yiping Luo Yaqi Liu Yan Chen Hui Jiang Dilixiati Duolikun Junjian Liu Wentao Cao Longpo Zheng |
| author_facet | Xinhui Wu Tianlong Wang Jinhui Zhao Lei Zhang Zhiqing Liu Yixing Chen Yiping Luo Yaqi Liu Yan Chen Hui Jiang Dilixiati Duolikun Junjian Liu Wentao Cao Longpo Zheng |
| author_sort | Xinhui Wu |
| collection | DOAJ |
| description | Abstract The repair of osteoporotic bone defects remains inadequately addressed, primarily due to a disruption in bone homeostasis, characterized by insufficient bone formation and excessive bone resorption. Current research either focuses on promoting bone formation or inhibiting bone resorption, however, the bone repair efficacy of these single‐target therapeutic strategies is limited. Herein, a “two‐way regulation” bone homeostasis strategy is proposed utilizing piezoelectric composite membranes (DAT/KS), capable of simultaneously regulating osteogenesis and osteoclastogenesis, with high piezoelectric performance, good biocompatibility, and excellent degradability, to promote bone regeneration under osteoporotic conditions. The DAT/KS membrane under ultrasound (US) treatment enables the controlled modulation of piezoelectric stimulation and the release of saikosaponin D (SSD), which promotes osteogenic differentiation while simultaneously inhibiting osteoclast differentiation and function, thereby effectively restoring bone homeostasis and enhancing osteoporotic bone repair. Mechanistic insights reveal the promotion of both canonical and non‐canonical Wnt signaling in bone marrow mesenchymal stem cells (BMSCs), which determines their osteogenic differentiation fate, and the downregulation of the NF‐κB signaling in bone marrow mononuclear macrophages (BMMs). This study presents optimized sono‐piezoelectric biomaterials capable of bidirectionally regulating both osteogenic and osteoclastic differentiation, providing a new potential therapeutic approach for pathological bone injuries. |
| format | Article |
| id | doaj-art-b44f91f43ebf4b019bf5d53b7de7649f |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-b44f91f43ebf4b019bf5d53b7de7649f2025-08-20T03:50:58ZengWileyAdvanced Science2198-38442025-07-011227n/an/a10.1002/advs.202504293Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis StrategyXinhui Wu0Tianlong Wang1Jinhui Zhao2Lei Zhang3Zhiqing Liu4Yixing Chen5Yiping Luo6Yaqi Liu7Yan Chen8Hui Jiang9Dilixiati Duolikun10Junjian Liu11Wentao Cao12Longpo Zheng13Department of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaDepartment of Prosthodontics Shanghai Stomatological Hospital & School of Stomatology Fudan University Shanghai 201102 ChinaDepartment of Orthopedics Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 ChinaAbstract The repair of osteoporotic bone defects remains inadequately addressed, primarily due to a disruption in bone homeostasis, characterized by insufficient bone formation and excessive bone resorption. Current research either focuses on promoting bone formation or inhibiting bone resorption, however, the bone repair efficacy of these single‐target therapeutic strategies is limited. Herein, a “two‐way regulation” bone homeostasis strategy is proposed utilizing piezoelectric composite membranes (DAT/KS), capable of simultaneously regulating osteogenesis and osteoclastogenesis, with high piezoelectric performance, good biocompatibility, and excellent degradability, to promote bone regeneration under osteoporotic conditions. The DAT/KS membrane under ultrasound (US) treatment enables the controlled modulation of piezoelectric stimulation and the release of saikosaponin D (SSD), which promotes osteogenic differentiation while simultaneously inhibiting osteoclast differentiation and function, thereby effectively restoring bone homeostasis and enhancing osteoporotic bone repair. Mechanistic insights reveal the promotion of both canonical and non‐canonical Wnt signaling in bone marrow mesenchymal stem cells (BMSCs), which determines their osteogenic differentiation fate, and the downregulation of the NF‐κB signaling in bone marrow mononuclear macrophages (BMMs). This study presents optimized sono‐piezoelectric biomaterials capable of bidirectionally regulating both osteogenic and osteoclastic differentiation, providing a new potential therapeutic approach for pathological bone injuries.https://doi.org/10.1002/advs.202504293bone homeostasisosteoporotic bone repairpiezoelectric stimulationtwo‐way regulationultrasound |
| spellingShingle | Xinhui Wu Tianlong Wang Jinhui Zhao Lei Zhang Zhiqing Liu Yixing Chen Yiping Luo Yaqi Liu Yan Chen Hui Jiang Dilixiati Duolikun Junjian Liu Wentao Cao Longpo Zheng Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy Advanced Science bone homeostasis osteoporotic bone repair piezoelectric stimulation two‐way regulation ultrasound |
| title | Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy |
| title_full | Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy |
| title_fullStr | Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy |
| title_full_unstemmed | Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy |
| title_short | Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy |
| title_sort | ultrasound responsive piezoelectric membrane promotes osteoporotic bone regeneration via the two way regulation bone homeostasis strategy |
| topic | bone homeostasis osteoporotic bone repair piezoelectric stimulation two‐way regulation ultrasound |
| url | https://doi.org/10.1002/advs.202504293 |
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