Nanotherapy for Neural Retinal Regeneration
Abstract Retinal diseases can severely impair vision and even lead to blindness, posing significant threats to both physical and mental health. Physical retinal regenerative therapies are poised to revolutionize the treatment of various disorders associated with blindness. However, these therapies m...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202409854 |
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| author | Chuyao Yu Li Dong Yujia Lv Xuhan Shi Ruiheng Zhang Wenda Zhou Haotian Wu Heyan Li Yitong Li Zhou Li Dan Luo Wen‐Bin Wei |
| author_facet | Chuyao Yu Li Dong Yujia Lv Xuhan Shi Ruiheng Zhang Wenda Zhou Haotian Wu Heyan Li Yitong Li Zhou Li Dan Luo Wen‐Bin Wei |
| author_sort | Chuyao Yu |
| collection | DOAJ |
| description | Abstract Retinal diseases can severely impair vision and even lead to blindness, posing significant threats to both physical and mental health. Physical retinal regenerative therapies are poised to revolutionize the treatment of various disorders associated with blindness. However, these therapies must overcome the challenges posed by the protective inner and outer blood‒retinal barriers. Nanotechnology applications in ophthalmology have shown great potential in addressing the issue of drug delivery to the eye. Moreover, nanotechnology‐based therapeutics can have profound clinical impacts on retinopathy, particularly retinal regeneration, thereby improving patient outcomes. Continuous advancements in nanotechnology are being applied to regenerate lost or damaged eye tissues and to treat vision loss and blindness caused by various retinal degenerative diseases. These approaches can be categorized into three main strategies: i) nanoparticles for delivering drugs, genes, and other essential substances; ii) nanoscaffolds for providing biocompatible support; and iii) nanocomposites for enhancing the functionality of primary or stem cells. The aim of this comprehensive review is to present the current understanding of nanotechnology‐based therapeutics for retinal regeneration, with a focus on the perspective functions of nanomaterials. |
| format | Article |
| id | doaj-art-b44dadebc6f649378d0ece313d89c1a4 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-b44dadebc6f649378d0ece313d89c1a42025-08-20T03:28:00ZengWileyAdvanced Science2198-38442025-06-011224n/an/a10.1002/advs.202409854Nanotherapy for Neural Retinal RegenerationChuyao Yu0Li Dong1Yujia Lv2Xuhan Shi3Ruiheng Zhang4Wenda Zhou5Haotian Wu6Heyan Li7Yitong Li8Zhou Li9Dan Luo10Wen‐Bin Wei11Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaBeijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaBeijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaBeijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaBeijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaBeijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaBeijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaBeijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology&Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Key Laboratory of Intelligent Diagnosis, Treatment and Prevention of Blinding Eye Diseases Beijing Tongren Hospital Capital Medical University Beijing 100730 ChinaAbstract Retinal diseases can severely impair vision and even lead to blindness, posing significant threats to both physical and mental health. Physical retinal regenerative therapies are poised to revolutionize the treatment of various disorders associated with blindness. However, these therapies must overcome the challenges posed by the protective inner and outer blood‒retinal barriers. Nanotechnology applications in ophthalmology have shown great potential in addressing the issue of drug delivery to the eye. Moreover, nanotechnology‐based therapeutics can have profound clinical impacts on retinopathy, particularly retinal regeneration, thereby improving patient outcomes. Continuous advancements in nanotechnology are being applied to regenerate lost or damaged eye tissues and to treat vision loss and blindness caused by various retinal degenerative diseases. These approaches can be categorized into three main strategies: i) nanoparticles for delivering drugs, genes, and other essential substances; ii) nanoscaffolds for providing biocompatible support; and iii) nanocomposites for enhancing the functionality of primary or stem cells. The aim of this comprehensive review is to present the current understanding of nanotechnology‐based therapeutics for retinal regeneration, with a focus on the perspective functions of nanomaterials.https://doi.org/10.1002/advs.202409854retinal regenerationretinal diseasenanotechnologynanoparticles |
| spellingShingle | Chuyao Yu Li Dong Yujia Lv Xuhan Shi Ruiheng Zhang Wenda Zhou Haotian Wu Heyan Li Yitong Li Zhou Li Dan Luo Wen‐Bin Wei Nanotherapy for Neural Retinal Regeneration Advanced Science retinal regeneration retinal disease nanotechnology nanoparticles |
| title | Nanotherapy for Neural Retinal Regeneration |
| title_full | Nanotherapy for Neural Retinal Regeneration |
| title_fullStr | Nanotherapy for Neural Retinal Regeneration |
| title_full_unstemmed | Nanotherapy for Neural Retinal Regeneration |
| title_short | Nanotherapy for Neural Retinal Regeneration |
| title_sort | nanotherapy for neural retinal regeneration |
| topic | retinal regeneration retinal disease nanotechnology nanoparticles |
| url | https://doi.org/10.1002/advs.202409854 |
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